Báo cáo y học: " Novel autoantigens immunogenic in COPD patients" pptx

... (Kyoto Encyclopaedia of Genes and Genomes) ribosome pathway. RPS6 is also involved in the insulin signalling and the mTOR signalling pathway. MCM3 and VIM are involved in the pathways cell cycle and ... higher immunogenicity in COPD sera Example for a protein macroarray analyzed with serumFigure 2 Example for a protein macroarray analyzed with serum. Since all clones are spotted in...

Ngày tải lên: 12/08/2014, 14:20

... rapid decline in lung function, particularly in the early stages of COPD, would require a study of reproducibility of FEV 1 and its decl ine in individual patients, possibly at short intervals ... of decline in the SGRQ total score increased linearly wi th each quarti le increase in the post-bronchodilator decline in FEV 1 (Figure 3). The range was from an improvement over time...

Ngày tải lên: 12/08/2014, 14:20

... phosphatases play relevant roles in the biology of the yeast (cell integrity, cell c ycle regulation, cation homeostasis, etc) and that they interact with several key signalling pathways. In some cases, ... rcelona, Spain. E-mail: Joaquin.Arino@uab.es Abbreviations: MAP kinase, mitogen activated protein kinase; TOR, target of rapamycin; PP1, type 1 protein phosphatase; PP2A, type 2A prote...

Ngày tải lên: 17/03/2014, 23:20

... locus previously identified in a multiplex family study [2]. UBASH3B and UBAC2 encode ubiquitin-associated proteins. The ubiquitin system is best described in targeting misfolded or damaged proteins for ... easy for a rare condition such as BD. The authors addressed this point by performing the initial analysis on pooled samples and then, having identified potential SNPs, validating the f...

Ngày tải lên: 09/08/2014, 14:22

... catheters inserted in major veins [6,7] and manual injection of fluid [8], to obtain desired result. Presently, rapid infusion systems (Haemonetics Corp., Braintree, MA) are commonly used to administer ... air embolism or hemolysis. We u sed Intrafix ® safeset (M/S B. Braun Melsungen, Germany) IV infusion assemb ly for infusing fluids instead of conventional IV tubing assem- bly, as this IV...

Ngày tải lên: 13/08/2014, 23:20

... Hydrogen bonding modulates binding of exogenous ligands in a myoglobin proximal cavity mutant. Biochemistry 38, 11086–11092. 30. Franzen, S. (2002) Carbonmonoxy rebinding kinetics in h93g myoglobin: ... proximal cavity mutant of Hb has recently demonstrated the key role of the proximal histidine in the cooperativity of quaternary structure change in response to ligand binding [4]. Str...

Ngày tải lên: 08/03/2014, 16:20

... with myositis. Medicine 2005, 84:231-249. 15. Targoff IN: Autoantibodies to aminoacyl-transfer RNA syn- thetases for isoleucine and glycine: two additional syn- thetases are antigenic in myositis. ... history, physical findings, and laboratory investiga- tions were obtained by retrospective medical record review using a standardized protocol. Written consent was obtained from treating phys...

Ngày tải lên: 09/08/2014, 10:20

... DeWoody K, Williamson P, Braun J, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Efficacy and safety of infliximab in patients with ankylosing spondylitis: ... Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A: A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Acti...

Ngày tải lên: 12/08/2014, 12:20

... analysis in 55 patients with COPD who had participated in two clinical Table 2: Minimal Clinically Important Difference (MCID) for the Clinical COPD Questionnaire (CCQ) by patient referencing. ... of these outcomes in the year following discharge from hos- pital for an acute exacerbation of asthma in a study in 238 individuals[4]. Similarly, in a study in patients with COPD...

Ngày tải lên: 12/08/2014, 16:20

... prophylaxis in trauma patients may be the lack of intra-institutional data concerning the inci- dence of clinically important bleeding. Only 27% of the institu- tions surveyed evaluated the incidence ... severe injury as defined by an Injury Severity Score greater than 16 and single-system injuries (e.g. head and spinal cord injuries) of the central nervous system [5]. However, the use of r...

Ngày tải lên: 12/08/2014, 19:21