Báo cáo y học: "Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways" ppsx

... p27 may have a compensatory role for the p53 pathway. Hypoxic pul- monary fibroblast proliferation may contribute to the progression of hypoxia-associated fibroblastic lung dis- eases and hypoxic ... PDGF on glycosaminogly- can synthesis by primary human lung cells. Am J Physiol Lung Cell Mol Physiol 2000, 279(5):L825-834. 7. Horino Y, Takahashi S, Miura T, Takahashi Y: Prolon...

Ngày tải lên: 12/08/2014, 14:20

... with T-lymphocytes leading to functionally significant responses by T-cells and fibroblasts. Methods: Human lung fibroblast were co-cultured with PMA-ionomycin activated T-CD4 lymphocytes for ... relevant to fibroblasts and lymphocytes activation, were evaluated by means of flow cytometry and RT-PCR. Proliferative responses of T lymphocytes to concanavalin A were evaluated by the...

Ngày tải lên: 12/08/2014, 18:22

... pathology between HTLV-1 and HTLV-2 has yet to be elucidated, it likely results from differential activities of the regulatory and accessory pro- teins. In addition to the typical structural and enzymatic ... has been clearly linked to the development of adult T-cell leuke- mia/lymphoma (ATL), an aggressive CD4+ T-lymphocyte malignancy, and various lymphocyte-mediated inflam- matory d...

Ngày tải lên: 12/08/2014, 23:22

... Products, Groningen, Netherland). The cells we re washed an d propidium iodide (5 μg/ml) wasadded.Apoptosisandviabilitywereanalyzedby flow cytometry (FACScalibur System, Becton Dickinson, San ... This maybeduetothemultiplerolesandinteractionsof ERK signaling. In summary, GM-CSF increases HIF-1a lev els and VEGF release by inducing ERK1/2 phosphorylation in a hypoxia-independent way. We ......

Ngày tải lên: 13/08/2014, 13:22

... histology is typically characterized by pronounced synovial hyperplasia, also called 'pannus'. The RA pannus produces proinflammatory cytokines and proteases, and invades carti- lage and ... previously reported. A genome-wide microarray-based gene expression analysis was conducted to identify genes and pathways that are differ- entially expressed between highly invasive DA...

Ngày tải lên: 09/08/2014, 10:23

... mediated lung injury. The normal airways (A) have the ability to export large amounts of both GSH and SCN into the ELF through CFTR and an unknown transporter to detoxify the relatively low amount ... hypertonic saline may afford some protection by increasing GSH in CFTR KO airways, this protective response is limited by t he inability to elevate their already deficient ELF SCN levels....

Ngày tải lên: 12/08/2014, 11:22

... BR, Deng LH, Shimoda LA, Sylvester JT: Effects of hypoxia in porcine pulmonary arterial myocytes: roles of K(V) channel and endothelin-1. Am J Physiol Lung Cell Mol Physiol 2000, 279:L262-L272. 54. ... as: Fuchs et al.: Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6. Respiratory Research 2011 12:20. Submit your next manuscript to BioMed Central and take...

Ngày tải lên: 12/08/2014, 13:22

... by inflammatory cells via their Fcγ receptors. This will activate these cells and cause the release of extra proinflammatory cytokines. D Various polymorphisms in proinflammatory cytokines and ... expressed in the RA synovium [6]. Of special interest is the PAD4 enzyme, which is normally present in the nucleus of granulocytes and CD14 + mono- cytes, because genetic polymorphisms in th...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 14:22

... [37]. Phenotypic capacitance The phenotypic capacitance reflects the variability in a panel of phenotypes induced by deletion of non-essen- tial genes and was used directly from the Levy and Sie- gal ... disorder); and, lastly, non-conserved disorder. Flexible disorder bears many of the characteristics commonly attributed to disorder and is associated with signaling pathways and mult...

Ngày tải lên: 09/08/2014, 22:23