... levels in ASMC. In asthma, inflammatory cellscan re lease cytokines that in turn induce increased cal-cium concentration i n ASMC, airway smooth musclecontraction, and airway hyper-responsiveness. ... Airway responsiveness of rats in the asthmaticgroup increased in comparison to the control groupafter induction by MCh (Figure 1).Inflammatory cells in BAL fluidThe number of inflammatory cells ... thesefindings, we conclude that WIN62577 plays a role in decreasing calcium concentration, which may ultimatelyalleviate airway inflammation and responsiveness. As aresult, substance P antagonist...