Báo cáo y học: " Nitric oxide gas phase release in human small airway epithelial cells" doc

... directly examined in airway epithelial cells of small airway origin. We hypothesized that primary human small airway epi- thelial cells (SAECs) would produce detectable NO gas phase release following ... by cytomix, SAECs and A549 cells increase gas phase NO release rapidly reaching a peak by 10 hours. The increase correlates temporally with an increase in iNOS p...

Ngày tải lên: 12/08/2014, 14:20

... caged: iso- Ins(1,4,5)P3/PM; IP 3 R: IP 3 receptor; NB-DGJ: N-butylde- oxygalactojirimycin; NB-DNJ: N-butyldeoxynojirimycin; NP-EGTA: Nitrophenyl-Ethylene Glycol-bis(β-Aminoe- thyl ether) N,N,N',N'-Tetraacetic ... Jones L, O'neal W, et al.: Chronic airway infection/inflammation induces a Ca2+i- dependent hyperinflammatory response in human cystic fibrosis airway epith...

Ngày tải lên: 12/08/2014, 14:20

... unknown precisely. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen- activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene and protein ... Access Research Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways Jeong Sup Song*, Chun Mi Kang, Moon Bin Yoo, Seung J...

Ngày tải lên: 12/08/2014, 15:20

... to evoke airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) in ... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is...

Ngày tải lên: 12/08/2014, 16:20

... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in ... NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In i...

Ngày tải lên: 26/10/2012, 09:07

... small pulmonary artery showing no immunocytochemical positivity for nNOS. (F) Control patient small pulmonary artery showing no positivity by immunocytochemistry for nNOS. × 400. Respiratory ... positivity also noted in media. (B) Small pulmonary artery from control patient showing very mild endothelial positivity for eNOS. (C) Cardiac patient small pulmonary artery showing iNOS...

Ngày tải lên: 12/08/2014, 14:20

... proteins modified by tyrosine nitration in acute respiratory distress syndrome. Am J Physiol 2000, 278:L961–L967. 31. Yi D, Ingelse BA, Duncan MW, Smythe GA: Quantification of 3- nitrotyrosine in ... of tyrosine nitration [16,20]. For instance, tyrosine nitration was suggested to have an effect on cellular pathways by affecting cytoskeletal proteins or tyrosine phosphorylation, thereby af...

Ngày tải lên: 12/08/2014, 18:20

... leukocyte– endothelium interaction is thought to assume major importance in this context. However, the role of nitric oxide (NO) in the interplay of inflammation, leukocyte–endothelium interaction and increased microcirculatory ... comparably increased accumulation of pulmonary leukocytes [6]. Furthermore, iNOS –/– caused enhanced pulmonary inflammation after instillation of lipopolys...

Ngày tải lên: 13/08/2014, 08:21

... α1AGP and haptoglobin and that the data were obtained only from the group of survivors. In addi- tion, defining the acute phase response by the indicated proteins is a narrowly defined approach, ... another. In rat, α1-acid glycoprotein (α1AGP), α2-macroglobulin (α2M), haptoglobin and thiostatin [6,8] are among the major acute phase proteins, whereas C-reactive protein, predominant i...

Ngày tải lên: 13/08/2014, 13:20

... predominance. 3 EPP is caused by a def iciency of ferrochelatase, the final enzyme in heme synthesis, which leads to an accumula- tion of pr otoporphyrin in various tissues, includ- ing the skin ... common presenting symptom among allergy practices. Angioedema is caused by increased vascular permeability in the subcuta- neous tissue of the skin and respiratory and gas- trointestinal t...

Ngày tải lên: 08/08/2014, 21:20