Báo cáo y học: "An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice" ppsx

... Access Research An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice Rosa ... prostaglandin E2 restrains airway mast cell activity in vivo and reduces airway eosinophilia and lung Th2 cytokine overproduction in a...

Ngày tải lên: 12/08/2014, 14:20

... loss causing pain, swelling, inflammation and joint immobility. Ultimately, a joint replacement may be required. However the processes result- ing in cartilage breakdown following injury and the ... relationship between joint injury and OA development has also been COX = cyclooxygenase; ELISA = enzyme-linked immunosorbent assay; GAG = glycosaminoglycan; IL = interleukin; MMP = matrix...

Ngày tải lên: 09/08/2014, 10:22

... sepsis. Materials and methods In an international survey 1058 physicians were interviewed for this study; they were interviewed after a random selection of 1100 physicians in Europe and the USA. Of ... 1058 physicians who were interviewed (including 529 intensivists) agreed that sepsis is a leading cause of death on the ICU and that the incidence of sepsis is increasing, but that...

Ngày tải lên: 12/08/2014, 20:20

... [11]. However, anti-inflammatory cytokines and cytokine inhibi- tors are also present in large quantities in RA joints. IL-10, produced by macrophages and partly by T cells in the syn- ovial tissue ... primary ligand-binding component type 1 IL-10R (IL-10R1) and the accessory component type 2 IL-10R [1]. The interaction of IL-10 and IL-10R engages the Janus kinase (JAK) family t...

Ngày tải lên: 09/08/2014, 01:24

... production only. Similarly, the ET-1-induced NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by ... via an increase in MMP and NO production. ET-1-induced stimulation of Figure 1 Effect of protein kinase inhibitors and LY83583 on endothelin-1 (ET-1)-induced MMP-13 and MMP-1 p...

Ngày tải lên: 09/08/2014, 06:22

... the synovial lining was demonstrated using TUNEL analysis of the sections, corresponding to the microscopic findings in hematoxylin and eosin staining. In addition, leukocyte infiltration into the synovial ... degree of TUNEL staining in synovial tissue sections. Investigators blindly reviewed primarily two areas: synovial lining and subsynovial regions. The extent of staining i...

Ngày tải lên: 09/08/2014, 07:20

... direct inhibition of ENaC, and interrupting K + recycling (Fig. 11). In sum- mary, CCB reagents decrease vectorial transepithelial Na + transport directly by inhibiting apical ENaC and indi- rectly ... delivered either intravenously or intratracheally. Indeed, nifedipine can- not prevent lung edema in mountain sickness [64]. As supported by our observations in permeabilized H441...

Ngày tải lên: 12/08/2014, 11:22

... cell-free assays, e.g. RNAse H digestion screens and oligonucleotide scanning arrays [9]. As activity in cell-free assay may not always correlate with activity in cellular systems, we developed in the present ... decrease in GST enzyme activity, as determined in a CDNB conjugation assay. AS-6 displayed potent and specific inhibition of GSTM1-1 enzyme activity. AS-5 and AS-10,...

Ngày tải lên: 31/03/2014, 15:20

... Gout may occur in any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity. In this case, although ... occurs in 90% of gout patients) or hyperpro- duction of uric acid [4]. Drugs that may cause hyperuricemia and gout include: diuretics, cyclosporine, low-dose aspirin, ethambuthol,...

Ngày tải lên: 25/10/2012, 10:06

... Oswestry Disability Index and Neck Disability Index for assessing functional disability due to low back and neck pain respectively. Standardised questionnaires such as the Short form 36 (SF36) and ... most and which they are seeking treatment for. A daily activity that is being restricted or prevented by these symptoms is also documented [4]. The MYMOP was initially published in 199...

Ngày tải lên: 25/10/2012, 10:06