Báo cáo y học: " The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice" pptx

... ancestry and from Germany, Poland, Finland and the United Kingdom [8-13]. The initial meta-analysis found the intronic sin- gle nucleotide polymorphism (SNP) rs1935062 the most promising marker ... of the patients, MM and MK contributed the data-analysis, interpretation of the data and drafting of the manuscript, GS initiated and coordinated the study. All authors...

Ngày tải lên: 11/08/2014, 16:22

... U6 snRNAs) and high alternative splicing frequency in U1 snRNP proteins, SR proteins and hnRNP proteins. The SR proteins and U1 snRNP proteins are involved in early steps of splicing and 5' and ... encoding splicing factors are duplicated in the genome, whereas some proteins, such as SF1/BBP (branchpoint-binding protein, which facilitates U2 snRNP binding in fission...

Ngày tải lên: 14/08/2014, 14:21

... small abdominal skin incision followed by another small inci- sion into the abdomen through the linea alba. The cathe- ter tip was positioned within the abdomen, the catheter secured in place, and the ... participated in the design of the study and drafted the manuscript. RW participated in the design of the study and its coordination. LM participated in t...

Ngày tải lên: 08/08/2014, 23:21

... was Protein levels of cytokines and chemokines in the lung homogenatesFigure 4 Protein levels of cytokines and chemokines in the lung homogenates. The 4 groups of mice were intratra- cheally inoculated ... CD80 in the lung were significantly greater in the CSBG + OVA group than in the other groups in vivo. Accordingly, the in vitro and in vivo data may lea...

Ngày tải lên: 12/08/2014, 14:20

... of the Raf-1 signal pathway inhibitor, GW5074, or the anti-inflammatory drug, dexamethasone, significantly suppressed the hyperresponsiveness of the airway contraction, while the airway epithelium-depend- ent ... exposed to sidestream smoke exhibit airway inflammation and hyperreactivity. Dexamethasone and a Raf-1 inhibitor are both able to suppress smok...

Ngày tải lên: 12/08/2014, 14:20

... chronic inflammation and hyperpla- sia of the synovial lining of joints. The expanding synovial tissue invades and subsequently destroys the underlying cartilage and bone. Increased cellularity is ... rheumatoid arthritis there is enlargement and increased cellularity of the synovial lining of joints, before invasion by the synovium of the underlying cartilage and bone....

Ngày tải lên: 09/08/2014, 01:21

... least the latter possibility seems highly unlikely, since the six cysteine residues coordinating the P-cluster i n the MoFe protein, are also conserved in the FeFe protein, as judged b y sequence ... of the P 1+ state in a weakly alkaline medium is likely to be caused by the simultaneous transfer of two electrons, thereby resulting in a transition from P N directly into...

Ngày tải lên: 18/03/2014, 01:20

... amino acids deleted. Changing the N-terminal residues Trp34 and Tyr74 to alanine results in abolition of the topoisomerase I activity while the methyltransferase activity remains intact. Keywords: ... resulted in a decrease in enzyme activity. Further deletions caused complete loss of activity. The N-terminus is a variable region present in many prokaryotic DNA (cytosine-5)...

Ngày tải lên: 24/03/2014, 00:21

... recorded only for the sequences encoding the interdomain linker peptides and the N- and C-terminal extensions. These findings certainly have an evolutionary significance. In both b-andc-type crystallin ... up the interface. Hence, in c-type crystallins the interdomain hydrophobic patches may not be the only determinant for domain association, whereas they are determinant an...

Ngày tải lên: 24/03/2014, 04:21

... of the inhibitory activity in the cell cycle. The activity of DNA polymerases in the nuclear extracts after neutralization of the inhibitory activity by spermidine hydrochloride Although the ... FEBS 2002 The inhibitory activity during the cell cycle The inhibitory activity during the cell cycle was measured in the p resence of 0.4 U of (added) purified DNA polymera...

Ngày tải lên: 31/03/2014, 21:21