... types, when activated, appearto play a central role in promoting and maintaining the dis-ease process [4,5], for example by producing certain sets of cytokines that influence the quality and ... study, samples of knee-joint SM,inguinal LNs, and spleen were obtained from rats killed atsix time points: day 0, 6 hours, day 1, day 3, and day 6 of AIA. Cytokine protein analysis was performed ... theproinflammatory or anti-inflammatory role of IL-5 in theacute phase of AIA.Systemic compartments In spite of its prominently local character, AIA is accompa-nied by a peak of IL-6 mRNA in the inguinal...