Báo cáo y học: " Profibrotic potential of Prominin-1+ epithelial progenitor cells in pulmonary fibrosis" docx

... Khoury SJ, Weiner HL, Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1- secreting Th3 T cells by oral administration of myelin ... these cells to T cells strongly inhibited the generation of cytotoxic T-lymphocyte activity by preventing the activation of CD8 + cells [14]. Other workers have also reported...

Ngày tải lên: 09/08/2014, 03:24

... joint involvement and rapid joint progression confirm observations that the frequency of CD4 + CD28 – T cells may correlate with the risk of occurrence of joint erosions in RA [18]. Competing interests None ... to activation-induced cell death. Moreover, these cells are characterized by intracellular storage of the cytolytic proteins perforin and granzyme B and are functionally...

Ngày tải lên: 09/08/2014, 01:22

... of the cases, providing an accuracy above 70% with a sensitivity and specificity of 93% and of at least 44%, respectively. The detection of complete Pfam domains, certainly easier to obtain in ... sensitivity and specificity can be achieved by analyzing the presence of non-truncated functional domains. Combining the latter with an assessment of the plausibility of the modeled...

Ngày tải lên: 09/08/2014, 22:23

... change that results in bypassing a proofreading mechanism of the Sec machinery [25]. The energy for precursor translocation is supplied by the hydrolysis of ATP by SecA and by the proton-motive ... mutation in secY reduced the pmf dependency of protein translocation [21]. Similarly, a single amino-acid substitution, replacing the helix-breaking glycine at position )10 in the hydro...

Ngày tải lên: 08/03/2014, 09:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4). The V s /V h r...

Ngày tải lên: 17/03/2014, 23:20

... treatment of ADHD [24-26]. In some cases, IR preparations are slowly titrated by weekly increments of 5-10 mg/day according to tolerability and the degree of efficacy observed, up to a maximum daily ... core symptoms of inattention, hyperactivity and impulsivity, patients often exhibit learning difficulties and impairment in social functioning. The frequency of referral is...

Ngày tải lên: 09/08/2014, 01:21

... line immunoblot assays (LIAs) for single-parameter or profile anal- ysis – have been established in clinical laboratory practice dur- ing past years, allowing examination of a large number of ... puri- fied by affinity chromatography from bovine thymus (>90% purity). This antigen (molecular weight 75 to 82 kDa) repre- sents a proteolytic degradation product of the predominant in...

Ngày tải lên: 09/08/2014, 01:22

... resulted in elevated levels of IL-1β protein in the synovium [41]. Intriguingly, blocking of IL-1α/β with neutralizing antibodies had no effect on the IL-17-induced synovial inflammation and joint ... Bersselaar L, Van den Berg WB: Reduction of interleukin-17-induced inhibi- tion of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. Arthrit...

Ngày tải lên: 09/08/2014, 06:22

... presumably of autoimmune ori- gin and is characterized by vasculopathy and fibrosis of the skin and internal organs. In the early stage of the disease, inflammatory infiltrates rich in T cells dominate ... Dayer JM: The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hin- dered by type I interleukin-1 solub...

Ngày tải lên: 09/08/2014, 07:20

... well [36]. By combining the therapeutic approach presented here with homing devices to, for example, target synoviocytes in the joint [37] or cells in the neointima in artery injury [38], a range of possibilities ... transfer of dnIκB into endothelial cells, adenovirus can be used as a vec- tor. Infection by adenovirus is initiated by the high affinity bind- ing of the carboxy-...

Ngày tải lên: 09/08/2014, 07:20