Báo cáo y học: " Simvastatin inhibits TGFb1-induced fibronectin in human airway fibroblasts" ppsx

... of simvastatin on TGFb1-induced fibronectin protein expression. Western analysis was performed using whole cell lysates obtained from primary human airway fibroblast cultures that were maintained ... airway wall fibrosis. Keywords: airway fibroblasts, airway remodeling, asthma, fibronect in, geranylgeranyl transferase, statins Background Chronic o bstructive airways diseases,...

Ngày tải lên: 12/08/2014, 14:20

... RASF finally cause the destruction of the joint [3]. As loss of integrity of compartment borders in the joint b etween cartilage and SF is a key event in RA, we were interested in analyzing molecular ... explain why normal SF are not inhibited in migra- tion by Slit3. This finding further supports the role of Robo3 in RA. A possible significance of our in vitro findings to the pat...

Ngày tải lên: 12/08/2014, 12:20

... determined by genome-wide expression profiling [14]. Beyond direct cartilage destruction, RASFs maintain inflam- mation in synovial joints and induce chondrocyte dysfunction by releasing proinflammatory ... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM rece...

Ngày tải lên: 09/08/2014, 01:22

... gain insight into the signaling pathway activated by HNE in human OA osteoblasts, we first examined the HNE-induced phosphorylation patterns of MAPKs over increasing periods of time. Our data indicated ... bone- resorbing cytokines and prostaglandins[11]. Among the pro- inflammatory mediators, interleukin-6 (IL-6) is a multifunctional cytokine involved in osteoclast recruitment and diff...

Ngày tải lên: 09/08/2014, 08:22

... Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zim- niak P, Awasthi YC: Transfection of mGSTA4 in HL-60 cells pro- tects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated ... articular chondro- cytes and as the main precursor for the synthesis of ECM gly- cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis in OA chondrocytes b...

Ngày tải lên: 09/08/2014, 13:21

... Sox9 stain- ing specificity was confirmed using human fetal growth plate cartilage, showing that the majority of cells in the surface, rest- ing, and proliferation zones positive and mostly negative ... patterns were mainly nuclear in normal cartilage (Figure 2), but Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure 3 Stem cell markers in human...

Ngày tải lên: 09/08/2014, 14:21

... likelihood of RV infecting the underlying smooth muscle during a naturally acquired RV infection in asthmatic subjects. Human airway smooth muscle (HASM) cells are actively involved in maintaining the ... Bardin P: Chemokine Responses In Primary Airway Fibroblasts Following Rhinovirus Infec- tion. Respirology 2004, 9:A76-A77. 39. Johnston SL, Papi A, Monick MM, Hunninghake GW: Rhi...

Ngày tải lên: 12/08/2014, 16:20

... prep- arations, including (1) laminin from EHS tumours that contains laminin type 1 (laminin 111) isoform, (2) affin- ity purified β1 chain-containing laminin from human pla- centa that includes laminin-1 ... (laminin 111), 2 (laminin 211), 6 (laminin 311), 8 (laminin 411), 10 (laminin 511) isoforms, and (3) affinity purified α2 chain-containing laminin from human placenta that consists o...

Ngày tải lên: 12/08/2014, 16:20

... [33,39,46]. In contrast, a recent study by Nicot et al. [47] have shown that p30 rather inhibits HTLV-I expression by binding to the tax/ rex-encoding doubly spliced viral RNA and retaining it in the ... amino acid identity and a similar domain structure that includes amino-terminal kinase domain, a dimerization leucine zipper domain, and helix-loop-helix motifs, which are involved in...

Ngày tải lên: 13/08/2014, 13:20

... compared to MODS in patients with brain injury [46]. Severity assessment based on nursing workload use The Therapeutic Intervention Scoring System (TISS) TISS was originally developed in 1974 to assess ... Metnitz P: The changing prognostic determinants in the critically ill patient. In 2007 Yearbook of Intensive care and Emergency Medicine. Edited by Vincent JL. Heidelberg: Spring...

Ngày tải lên: 13/08/2014, 20:21