Báo cáo y học: " Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury" doc

... NA. Epithelial cell senescence is accompanied by severer airway inflammation Since the repair process after NA injury is accompanied by airway inflammation, we next evaluated the severity of airway ... activation. Conclusions: Senescence of airway epithelial cells impairs repair processes and exacerbates p38 MAPK-dependent inflammation after airway inj...

Ngày tải lên: 12/08/2014, 13:22

... Kopecky SL, Frye RL, Goronzy JJ, Weyand CM: T -cell- mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002, 105:570- 575. 84. Nakajima T, Goek O, Zhang X, Kopecky SL, Frye ... goronzy.jorg@mayo.edu Arthritis Research & Therapy Vol 5 No 5 Goronzy and Weyand 231 with ankylosing spondylitis. Namekawa and colleagues [54] demonstrated the presence of these cells...

Ngày tải lên: 09/08/2014, 01:23

... reperfusion injury. Our results suggest that massive EC death shortly after reperfusion may cause pulmonary edema and pul- monary hypertension mediated by endothelial cell dys- function [6,11]. ... injury and prevents EC dysfunction in several models of acute lung injury [12]. Pentoxifylline administration to patients with ischemic cardiomyopathy inhibited pro- inflammatory cytokines...

Ngày tải lên: 12/08/2014, 15:21

... type-dependent, with HeLa and T-cells showing predominantly plasma membrane assembly and primary macrophages displaying a high level of MVB-associated assembly. Real-time imaging of infected cells ... influence of cell biology in retrovirus research, we recently organized a Summer conference sponsored by the American Society for Cell Biology (ASCB) on the Cell Biology of HIV-1 and...

Ngày tải lên: 13/08/2014, 09:20

... many phenotypesthatare not shared with CAF-1 mutants, including growth defects, sensitivity to double- strand DNA damage, sensitivity to hydroxyurea, suppres- sor of Ty or Spt phenotype, and ... chromatin assembly factors that have been identified biochemically and may function to mediate chromatin assembly in vivo: histone chaperones for newly synthesized H3 and H4 (ASF1 and CAF-1) a...

Ngày tải lên: 31/03/2014, 21:21

... space and systemic circulation by/with lymphatic absorption from pleural surfaces and by exposing the subpleural microvessels and microlymphatics of the loose connective tissue layer directly to ... doxycycline and minocycline have been used for pleurodesis [1,13,14]. Oxytetracycline, a derivative of Streptomyces rimosus, wasintroducedin1950andhasbeenaneasilyaccessi- ble drug in Turke...

Ngày tải lên: 10/08/2014, 09:23

... prior to bronchoscopy. Collection of Airway Epithelial Cells Epithelial cells from the large and small airways were col- lected using flexible bronchoscopy. After achieving mild sedation and anesthesia ... previously described [13]. The large and small airway epithelial cells were subsequently collected separately in 5 ml of LHC8 medium (GIBO, Grand Island, NY). An aliq uot...

Ngày tải lên: 12/08/2014, 11:22

... effects of PLV after surfactant depletion in a rabbit model by morphometry at the light microscopic level and by qualitative electron microscopy. By reporting the number of type II cell profiles ... baseline and 30 and 60 minutes of therapy. Fixation, sampling and processing All lungs (n = 5 per group) underwent light and electron microscopical as well as stereological analysis....

Ngày tải lên: 12/08/2014, 15:20

... upon damage to the cell membrane. In addition, adenine nucleotides can be extracellularly hydrolyzed to adenosine. Hydrolysis is media- ted by the two enzymes ectoapyrase (CD39) and ecto-5’- nucleotidase ... nervous system and various other peripheral tissues [24]. In ADA -/- mice A 1 expression was identified on endothelial cells, airway epi- thelial cells and alveolar epithelial...

Ngày tải lên: 13/08/2014, 11:22

... a 'post-pump' syndrome characterised by a systemic inflamma- tory response syndrome and its anti-inflammatory counterpart, termed the compensatory anti-inflammatory response syn- drome [20]. IL-18 plays ... cardiopulmonary bypass (CPB) surgery [1]. IL-18 is a key cytokine regulator of this bal- ance that, among other clinical and cytokine measures, stands out as predictive of or...

Ngày tải lên: 13/08/2014, 11:23