... between aa122 and aa123 [15,16], 3-aa insertionbetween aa123 and aa124 [16], 1-aa insertion betweenaa121 and aa122 [20], 3-aa insertion between aa1 18 andaa119 [ 18] , 2-aa deletion from aa110 to aa111 ... Alexopoulou A, Baltayiannis G, Jammeh S, Waters J, Dourakis SP, Karayiannis P: Hepatitis B surface Antigen variant with multiple mutations in the α determinant in an Agammaglobulinemic patient. J Clin ... no insertion/deletion was found [14]. The origin of variant HBsAg was unclear. The patienthad no history of vaccination, therapy with interferon-α/nucleoside analogues, administration of hepatitis...