Báo cáo y học: " Claudins in lung diseases" ppt

... [23]. This link between proinflammatory cytokines and osteoclast formation most likely explains why cytokine-targeted therapy, particularly blockade of TNF, is highly effective in retarding structural damage ... lineage types such as Kupffer cells in the liver or microglia in the brain. It is not fully clear whether some monocytes entering an inflamed joint are already committed to the...

Ngày tải lên: 09/08/2014, 01:22

... (Panels 4,5) Increased urinary excretion rates of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross- link products, expressed relative to creatinine (Cr), were observed during the active ... of collagen cross-links as a biomarker of joint erosion Joint tissues contain different quantities of the major cross- links hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP), which ar...

Ngày tải lên: 09/08/2014, 06:23

... biological activity of any cytokine in biological fluids can be interpreted correctly only by taking into account the activities of other synergistic or antagonistic cytokines, of their respective inhibitors, ... destructive disease, it is not well appreciated that the main problem is in fact the inhibition of repair activity. Any type of chronic joint inflammation, whethe...

Ngày tải lên: 09/08/2014, 14:22

... thereby initiate the infection process [1-4]. The cleavage site of HA0 of most avian and mam- malian influen za viruses is monobasic and carries a sin- glearginine,rarelyasinglelysineaminoacid.Cleavage has ... Switzerland). This substrate contains an alkaline amino acid (arginine) in theP1siteupstreamthep-NA group that favors proteolysis by trypsin like serine proteases at alkalin...

Ngày tải lên: 11/08/2014, 21:21

... during embryonic development and postnatally. The cause of the postnatal lethality is not fully understood yet. In this paper, we reported lung structural defects in HO-1 mutant animals including ... Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, Choi AM: Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung inju...

Ngày tải lên: 12/08/2014, 11:22

... origin as Lin − /7-aminoactinomycin D (7AAD) − / CD34 + /CD133 + /VEGFR-2 + cells and the number of these cells was indeed higher in RA patients compared with controls. In addition, the colony-forming ... late-outgrowth EPCs of solely heman gioblastic origin may be involved in vascular repair. As this EPC subset may be preferentially involved in the active stage of the disease, i...

Ngày tải lên: 12/08/2014, 11:23

... parasite infections may be associated with tight junctional changes in the pul- monary cells. Claudins in lung injury and inflammation ARDS (Acute respiratory distress syndrome) is due to injury of ... Expression of claudins in lung cells has been compiled in Table 1. Claudins in embryonic development of the lung Clau dins are involved in embryogenesis and organogen- e...

Ngày tải lên: 12/08/2014, 13:22

... 2006, 11:217-220. doi:10.1186/1465-9921-12-97 Cite this article as: Kawase et al.: Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. Respiratory Research 2011 ... utility of monitoring KL-6 in EGFR-TKIs induced ILDs. Conclusions Our results indicate that the change in serum...

Ngày tải lên: 12/08/2014, 13:22

... bleomycin 6 in bleomycin6 in bleomycin 6 in bleomycin- -induced lung induced lung induced lung induced lung inflammatory changes in mice inflammatory changes in miceinflammatory changes in mice inflammatory ... bleomycin bleomycinbleomycin bleomycin- -induced pulmonary inflammation in the rat induced pulmonary inflammation in the ratinduced pulmonary i...

Ngày tải lên: 12/08/2014, 14:20

... extensively studied in terms of cardiovascular effects. We have found that the ANP-NPRA signaling pathway is also involved in airway allergic inflammation and asthma. ANP, a C-terminal peptide (amino acid 99–126) ... Knockout of NPRA in mice resulted in less lung inflammation [11]. Inhibition of NPRA by small inferfer- ing RNA against NPRA attenuated lung inflamma...

Ngày tải lên: 12/08/2014, 14:20

... significantly related to FEV 1 and to FVC. Table 3: Association of inflammatory markers and lung function in school children living in Mexico City with exposure to Fruit and vegetable index and Mediterranean ... function and airway inflammation among Mexico City school children exposed to high levels of air pollutants. Materials and metho...

Ngày tải lên: 12/08/2014, 14:20

... similar model of mild pulmonary edema[20]. Therefore, this study provides the first data concerning modifications in the overall mechanical properties of the respiratory sys- tem in vivo during interstitial ... Contributed in the design of the study, in writing the manuscript, in the design and development of the experi- mental set-up and the da...

Ngày tải lên: 12/08/2014, 15:21

... 171:261-268. 64. Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y: Anti-vascular endothelial growth factor gene therapy attenuates lung injury and ... not for citation purposes) Respiratory Research Open Access Review Angiogenesis in Interstitial Lung Diseases: a pathogenetic hallmark or a bystander? Argyris T...

Ngày tải lên: 12/08/2014, 16:20

... Kale P, Winograd R, Gupta MV, Heydarian M, Berro R, McCaffrey T, Kashanchi F: HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. ... avenue, whereby stochas- ticity of viral integration events could differentially mod- ulate the expression of tightly regulated factors, culminating in neoplasia. The effect of viral...

Ngày tải lên: 13/08/2014, 05:22

... faculty, in the sciences and the humanities. Some colleagues - nearly all fellow econ- omists, interestingly - rushed to his defense, claiming that he was performing a valuable service by focusing ... should have put my brain in gear before letting up the clutch on my tongue. (When I was inter- viewed for my first job, I actually said, “Oh, salary isn’t that important to me.” They never f...

Ngày tải lên: 14/08/2014, 14:21