Báo cáo y học: " Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine" pdf
Báo cáo y học: " Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine" pdf
... Access Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporineTimothy Floreth†, Eric Stern†, Yingli Tu, Randi Stern, Edward R Garrity Jr, Sangeeta ... actin.Conclusion: Transplant derived differentiated airway epithelial cell IL-6, IL-8, and TNF-a secretion is not regulated by cyclosporine in vitro; these cells thus may participate in local inflammatory responses ... Forrest IA, Murphy DM, Johnson GE, Robertson H, Cawston TE,Fisher AJ, Dark JH, Lordan JL, Kirby JA, et al: Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition...
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Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor" docx
... therapy. Thus, in this study the synovialexpression of IL-15 in RA was not consistently influenced by TNF blockade, being apparently independent of TNF expressionin the synovium. Consequently, ... fac-tor alpha blockade reduces the synovial cell infiltrate earlyafter initiation of treatment, but apparently not by induction ofapoptosis in synovial tissue. Arthritis Rheum 2003,48:2155-2162.21. ... the cell infiltrate in synovial tissue by dig-ital image analysis. Rheumatology (Oxford) 2000, 39:43-49.17. Smeets TJ, Kraan MC, Versendaal J, Breedveld FC, Tak PP: Anal-ysis of serial synovial...
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Báo cáo y học: " The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference" pps
... virion core is released into the cyto-plasm. This coneshaped core consists of the capsid (CA-p24) protein containing the RNA genome and viralenzymes. This core is dissolved only partially during ... drop in GFP-expressing cells is therefore caused by direct RNAi-inhibition of the reporter transcript, and not by targeting of the incoming RNA genome.DiscussionWe have not observed RNAi-mediated ... theincoming genome could not reduce the transduction effi-ciency. Given the size of the RISC complex, it is likely thatRISC cannot enter the viral particle, thereby explainingour results.ConclusionUsing...
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Báo cáo y học: "SPLUNC1 regulation in airway epithelial cells: role of toll-like receptor 2 signaling" ppsx
... air-way epithelial lining fluid. was calculated at 5.3 ±2.1 μg/ml.Statistical analysisFor normally distributed data, one-way analysis of var-iance (ANOVA) was used for multiple comparisons, ... fluorescent dye (e.g., IRDye® 800), anddetected by using the Odyssey Imaging System. Densito-metry was then performed to quantify SPLUNC1 pro-tein levels. Intracellular SPLUNC1 protein of human epithelial ... increased SPLUNC1 production in airway epithelial cells, respectively.Conclusions: Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1...
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Báo cáo y học: "Time course of airway remodelling after an acute chlorine gas exposure in mice" pdf
... on airway cell apoptosis; TUNEL techniqueFigure 3Effect of Cl2 exposure on airway cell apoptosis; TUNEL technique. A: Control mouse airway, showing baseline airway epithelial cell apoptosis ... sections and by scoring of airway fibrosis on Picrosirius red stained tissue sections.Goblet cell numbers were assessed by light microscopyand standard morphometric techniques. Airway histologywas ... epithelium, as wasobserved in many airways in this study. In this instance,growth and differentiation of local progenitor cells is another mechanism by which the epithelial layer can berepopulated....
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Báo cáo y học: "Protein-losing enteropathy in patients with Fontan circulation: is it triggered by infection" ppt
... Ltd(Print ISSN 1364-8535; Online ISSN 1466-609X). This is an OpenAccess article: verbatim copying and redistribution of this article arepermitted in all media for any purpose, provided this notice is preserved ... were quantified by ELISA (R&D Systems, Wiesbaden, Germany and IBLGmbH, Hamburg, Germany, respectively). The concentrationof the complement fragment C3d was determined by radio-immunodiffusion ... circulation.Its pathogenesis is not fully understood, however, and it is unclear why its onset occurs months oreven years after Fontan surgery.Patients We report a 4.5-year-old girl with Fontan...
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Báo cáo y học: "Open Access Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbin" pdf
... proteinwas detected by immunoblot analysis in the two HTLV-1-transformed T -cell lines but not in the ATLL -derived T -cell line (data not shown). Cell viability was assessed by thewater-soluble ... T -cell malignancy caused by infection of mature CD4+ T cells by human T -cell leukemia virus type 1 (HTLV-1) [1-3]. ATLL is clinically and hematologically subclassified into foursubtypes: acute, lymphoma, ... onHTLV-1-infected T -cell lines (i.e., by inhibiting NF-κB andAP-1 activity). Inhibition of NF-κB activity is mediated by blocking the phosphorylation of the NF-κB inhibitoryprotein IκBα and by preventing...
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Báo cáo y học: " Off hour admission to an intensivist-led ICU is not associated with increased mortality" pps
... quality of careare mostly about ICUs without 24-hour intensivist coverage.The present study is not informative on this subject. Finally,hospital mortality is only a small part of quality of ... 30:895-901.Key messages• In this study in three intensivist-led ICUs, daytime was defined by the time period in which intensivists are rou-tinely present in the unit and off hours was defined by the ... theorganisational model with intensivists present during the dayand residents supervised by intensivist during off hours is ade-quate enough to avoid a 'quality gap' during off hours.This...
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Báo cáo y học: "Dividing intensive care specialists according to their backgrounds is not useful to improve quality in intensive care" ppt
... results should only be viewed as hypothesis-generating given the retro-spective design of the study’ [1]. We are concerned that this potentially divisive hypothesis is not founded on sound ... confounding factors in this study that are not addressed by studies such as this. We call for attention to remain focused on the major hurdles facing all physicians in modern-day intensive care medicine: ... intensive care specialists according to their backgrounds is not useful to improve quality in intensive careJan-Peter Braun* and Claudia SpiesSee related research by Billington et al., http://ccforum.com/content/13/6/R209LETTER*Correspondence:...
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Báo cáo y học: "Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsivenes" pdf
... this is not the casewith anticholinergics.23Salbutamol is a potent broncho-dilator, but it could also inhibit cysteinyl leukotrienesynthesis by the airway cells.24Asthma is a complex disorder ... presence of airway hyperresponsiveness. Methacholine chloride is asynthetic derivate of acetylcholine, which is a parasympa-thetic neurotransmitter that is very important for airway smooth muscle ... in this study has failed given the complexityof chronic airway inflammation and remodelling inasthma, even if the activity of allergy-related airway inflammation is known.In this study, responses...
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