Báo cáo y học: " Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD" pps

... article Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus Seung-Ki Kwok 1 *, June-Yong ... inhibition of TLR signaling via dys- regulation of lipopolysaccharide-induced TLR4-MyD88 com- Figure 5 Expression of IFN-α signature genes Expression of IFN-α signature genes...

Ngày tải lên: 09/08/2014, 10:23

... expectancy and do not require phlebotomy. The therapies used for polycythemia vera such as phlebotomy and chemotherapy should not be used in patients who have polycythemia due to high affinity Hb ... other symptoms. Past medical history was unremarkable. Family history was significant for lifelong history of polycythemia in her mother, maternal grandmother and her younger sister....

Ngày tải lên: 08/08/2014, 16:23

... practice, lack of efficacy with the standard dose of 3 mg/kg of infliximab results in many patients using higher doses; as many as 61% of patients with rheumatoid arthritis after 1 year of use receive, ... and biologically plausible, but they also fulfill the dose-effect criterion for causality. The low risk in the comparison group may be real, the result of chan...

Ngày tải lên: 09/08/2014, 08:22

... this group of patients. The results of this study support the findings of the present study, since Kanazawa and col- leagues hypothesized that vascular remodeling in the pul- monary arteries of bronchitis ... or ex-smokers [2 1- 25]. In bronchitis type of COPD airway inflammation is characterized by an influx of inflammatory cells, predom- inantly neutrophils, macrop...

Ngày tải lên: 12/08/2014, 15:21

... seen by computed tomogra- phy scan in ARDS patients is caused by open alveoli flooded with edema rather than by atelectasis [23]. Perhaps the dorsal injury seen on the computed tomography scan ... demonstrated that lung injury was very regional but that the most severe injury always occurred in the dorsal portion of the lung regard- less of whether the dorsal lung wa...

Ngày tải lên: 13/08/2014, 08:20

... ability of antioxidants in the sample to inhibit the ox- idation of ABTS ® (2,2'-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS ® · + by methmyoglobin. The capacity of the antioxidants ... number of the patients may be the cause of the limited difference between groups. Limitation The major limitation of the study is small num- ber of the...

Ngày tải lên: 25/10/2012, 11:00

... which they consider whether carotid artery intima-media thickness (IMT) - a surrogate marker of athero- sclerosis - might be a good predictor of future cardiovascular events in patients with rheumatoid ... at the time of evaluation by carotid ultrasonography. In our study carotid IMT, categorized in quartiles, was strongly associated with cardiovascular events; specifi...

Ngày tải lên: 09/08/2014, 10:23

... es with ana- kinra, a non-glycosylated form of the endogenous antago- nist of the IL-1 receptor, IL-1Ra, and rilonacept, which binds to IL-1b with high affinity and thus blocks the binding of ... e associated with over-activation of caspase-1, the enzyme which catalyses the c leavage of the precursor of IL-1b, pro-IL-1b, to generate a ctive IL-1b in excess [9]. T...

Ngày tải lên: 12/08/2014, 15:22

... respectively. Two of the patients were oliguric the day before, and the patient with early dialysis (day 5) was oliguric 4 days before. Three of the dialysed patients died. Factors of importance in the ... per year during the study period. (See selec- tion of patients in Figure 1.) For the majority (14 of 17) of the excluded patients who died within 2 d...

Ngày tải lên: 13/08/2014, 11:23

... 2008, 155:48 7-4 93. doi:10.1186/146 5-9 92 1-1 2-1 8 Cite this article as: Rennard et al.: Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD. Respiratory Research ... receive short-acting anticholi- nergics (Table 1). Exacerbations The rate of moderate-to-severe...

Ngày tải lên: 12/08/2014, 13:22