Báo cáo y học: " Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes" pptx
Báo cáo y học: " Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes" pptx
... flow cytometry (see below).Flow cytometryThis technique was used to assess the purity of the cellsuspensions and to characterize their phenotype aftercytokine stimulation. Cells were first incubated ... on cytokine-activated cells. To mimic inflammation, we chose to analyze the effect onthe AECII phenotype of two major inflammatory cyto-kines, IFN-g and TNF-a, known to mo dulate some of these ... are rather difficult to obtain.The aim of the study was to compare both modelsand to define the most suitable one to study antigen presentation. In this paper, we report a detailed pheno-typic...
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Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... suggests that this cell type may be another criticaltarget for the treatment of inflammatory arthritis [11].Mesenchymal stem cells (MSCs) are cells of stromalorigin that can exert profound ... immu-nohistochemistry in the joints of UC-MSC-treated mice,suggesting that injected UC-MSCs did not restore tissueintegrity by mechanisms of tissue repair (data notshown).However,wewereabletodetectthesecellsatintermediate ... inflammatoryinfiltrates in the synovium of mice treated w ith human UC-MSCs. Moreover, UC-MSCs increased the levels of the antiinflammatory cytokine IL-10. Aside from its roleas an antiinflammatory...
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Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
... sur-rounding tissues [4]. Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types. In the field of cell transplantation, MSCs have many advantages ... mi-gration of MSCs were dynamically monitored to evaluate the feasibility and safety of intravenous im-plantation of allogeneic MSCs in the treatment of femoral head necrosis. Our study may provide ... blood supply to necrotic femoral head [39]. Liu et al conducted a phase I clinical trial to evaluate the feasibility and safety of intravenous transplantation of stem cells. In their study, MSCs...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... especially withrespect to its glycone/aglycone speci®city a nd ability to catalyse the hydrolysis of dietary xenobiotic glycosides. Thisis also the ®rst report describing heterologous expression of a ... b-D-arabino-sides), similar to the native enzyme. For the ®rst time, weshow that the human enzyme has signi®cant activity towardsmany common dietary xenobiotics including glycosides of phytoestrogens, ¯avonoids, ... (5¢-TTTTT T GGATCCCTACAGATGTGCTTCAAGGCC-3¢), thusintroducing XhoIandBamHI sites, respectively (underlined)at each end of the gene. The 5¢ terminus of this construct wasdesigned to introduce t...
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Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot
... topoisomerase T7 22A mutation that increases the stability of Topo I–DNA covalent complex, thus mimicking the cytotoxic effect of camptothecin [9], has also rendered low viability of theyeast mutant carrying ... treatingcancers that are refractory to camptothecin treatment. Inorder to understand the structure–activity relationship of TDP and to facilitate inhibitor screening in a highthroughput manner, we ... concentration; l,pathlength). The requirement of cofactor for TDP enzymaticactivity was examined by determining the specific activity of TDP by following the cleavage of 1 mM of substrate by0.125...
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Báo cáo y học: " Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma" ppt
... modified myoepithelial cells of the stromal tissues. Furthermore, the cyto-proliferation of these modified myoepithelial cells continued to the bone forming cells, which reacted to Runx2, ... well-known osteoblastic maker. Therefore, the results strongly suggest that the bone forming cells (osteoblasts and osteocytes) originated from the modified (neoplastic) myoepithelial cells. This ... modified myoepithelial cells, and other from undifferentiated mesemchymal cells of true stromal tissue, including the possibility that one of the metaplastic factors was neoplastic cells producing...
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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... dependent and were not neutralized by anti-TGF-βor IL-10. Adding less than 1% of these cells to T cells strongly inhibited the generation of cytotoxic T- lymphocyteactivity by preventing the activation ... extremely potent suppressive activity. TheseCD4+ cells had the phenotype and functional characteris-tics of ‘professional’ regulatory T cells. Using the genera-tion cytotoxic T- cell activity and ... differentiationpathway of CD4+regulatory T cells. Following T- cell activation where asufficient amount of IL-2 is produced to overcome the inhibitory effects of TGF-β, the costimulatory effects of...
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Báo cáo y học: "Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts" doc
... the type of Th cell that stimulates them. This is consistent with thecapacity of fibroblasts to activate flexible patterns of cytokineproduction readily. A corollary of this observation is the ... NP40 to detect cytokine content.Statistical analysisStudent's t test was used with two-tailed P values or Mann–Whitney U test using StatView 5.0™ (SAS Institute Inc., Cary,NC) software ... to a lesser extent by Th1 cells –an effect due to cytokines (IL-1 and TNF-α) shared by the two T cell subsets. This indicates that the biological activities of T cells do not simply mirror the...
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Báo cáo y học: " Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy" ppt
... might also contribute to the pathophy-siology of the disease. To evaluate this possibility, weconducted an experiment to investigate the expressionlevels of wild -type and mutant proteins in the ... cytosolic (Cy) and mitochondrial (Mi) extracts from T- REx-293 cells transiently transfected with the wild -type or NDUFV2pathogenic mutant construct. (c) The expression levels of the wild -type ... mutation to evaluate the effects of these changes on mitochon-drial import but all of the single-point mutants showedan import efficiency comparable to that of the wild -type NDUFV2 (data not...
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Báo cáo y học: "Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem " pptx
... of immunity display an extraordinary capacity to induce T cell responses and secrete a variety of cytokines; thedifferentiation status of DCs can influence whether itstarget lymphocyte–often T cells will ... potent antigen- presenting cells (APCs) that act by internalizing, shut-tling, and presenting antigens to naïve T -cells, whichthen leads to T- cell a ctivation. These key regulators of immunity ... known to be a good source for the hematopoietic stem cell, one type of highl y used stem cells. Known to be important inmediating the fetomaternal tolerance o f p regnancy, fetal-stage extra-embryonic...
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