Báo cáo y học: " Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats" ppsx

... The cyclin-dependent kinases inhibitors include INK4 family and cip family which can inhibit the activity of the CDK-cyclin complexes. The Cip/Kip family can inhibit all cyclin/CDK complexes in ... 11:182 http://respiratory-research.com/content/11/1/182 Page 7 of 11 RESEARC H Open Access Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the...

Ngày tải lên: 12/08/2014, 13:22

... Spies 3 1 Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité University Hospital Berlin, Berlin, Germany 2 Professor of Cardiac Surgery, Department of Pediatrics, ... Benjamin Franklin, Charité University Hospital Berlin, Berlin, Germany 3 Professor of Anesthesiology, Department of Medical Statistics and Clinical Epidemiology, Campus Benjamin...

Ngày tải lên: 12/08/2014, 20:20

... elevated hepcidin and Hb decrease in sep- tic patients. However, the causal relation of the induction of hepcidin by IL-6 and the development of anemia by sustaining elevated hepc idin levels has ... prototypical acute inflammatory syndrome frequently complicated by the development of anemia. As the incidence of sepsis is high [12], determi- nation of this putati...

Ngày tải lên: 14/08/2014, 07:21

... Perinatal brain injury is the leading cause of subsequent neurological disability in both term and preterm baby. Glutamate excitotoxicity is one of the major factors involved in perinatal hypoxic- ischemic encephalopathy ... brain injury in neonates is defined as hypoxic- ischemic encephalopathy (HIE) which is the leading cause of neurological sequelae in premature infan...

Ngày tải lên: 10/08/2014, 10:20

... production by HC pul- monary Treg (Figure 4D). Furthermore, this reduction in IL-10 expression by HC pulmonary Treg mediated by AA BAL was reversed by neutralizing TSLP with 10 μg/ ml of a blocking ... 11 of 11 IL-10 production, which was correlated with the increased expression of TSLP in BAL of these s ubjec ts. Consistent with the potential role of TSLP in...

Ngày tải lên: 08/08/2014, 21:20

... magnitude may be relatively independent, and that the magnitude of an antibiotic response is unlikely to be improved by extending treat ment beyond 14 days. The profiles of mean daily changes in FEV 1 from ... baseline through day 14 by treatment group are consistent with this hypothesis, in that the relative amplitudes of the profiles differ but their shapes are similar...

Ngày tải lên: 12/08/2014, 11:22

... 15:R23 http://ccforum.com/content/15/1/R23 Page 7 of 10 of DAA and therapeutic dose enoxaparin has not been investigated in this model. Therewerenosignsofasystemicprofibrinolytic effect of enoxaparin, or the combination of enoxaparin with ... generation may lead to a drop in plasminogen activation by tPA, which is dependent upon the cofactor activity of fibrin [8,9] thus r...

Ngày tải lên: 14/08/2014, 07:21

... Gly23 of birtoxin (Fig. 4). In ikitoxin the presence of Glu23 charge preceding the a-helix modifies the activity of this toxin in a unique way to result in reduced potency in mice. The C-termini of ... which the symptoms faded and the mice completely recovered. Ikitoxin did not show lethality during the course of the observation period in the range of in...

Ngày tải lên: 31/03/2014, 08:20

... determine the level of disease or quantifying the patient’s myocardial ischemic burden at the time of the testing. Resting ECG analysis, including that of the 12-lead ECG, typically has significantly ... Technology Overview The Premier Heart 3DMP technology investigated in this study is based on systems theory, in which mathematical modeling is used in the ana...

Ngày tải lên: 08/08/2014, 16:23

... methods can only be drawn indirectly from other studies. In conclusion, the mathematical analysis of the ECG by 3DMP appears to provide sensitivity and specificity for the prediction of relevant ... electrocardiography, computer-enhanced, coronary imaging: angiography, sensitivity, specificity, post-intervention Introduction Coronary artery disease (CAD) is the leading...

Ngày tải lên: 08/08/2014, 17:20