Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx

... regulating mucus overproduction in smoke inhalation injury. In the present study, MUC5AC protein expression was increased within 4 hour after 15 min smoke inhalation. The expression was sustained ... and also in a combined burn and smoke inhalation injury model [6] , but the mechanism by which smoke damages the airway still remains unclear. In our mouse model of smo...

Ngày tải lên: 12/08/2014, 13:22

... phosphorylation /activation of proteins by immunoblotting assay. Phosphorylation of JNK1 /2 was significantly induced within 15 min in response to PGE2 stimulation, and was maintained up for 24 ... (Figure 3B). The findings suggested that admin- istration of PGE2 may induce the motility of human colon cancer by inducing the activation of JNK1 /2. 17b-Estradiol Inhibits PGE2-Induced E...

Ngày tải lên: 10/08/2014, 10:20

... Glycerol-induced kidney injury ↓ Cisplatin-induced kidney injury 2C11 ↓ Uranyl nitrate induced kidney injury 2D2 ↔ Nephrectomy ↔ Bilateral ureteral ligation ↔ Glycerol-induced kidney injury ↔ ... MMAAP is usually cleared by hepatic metabolism to N-formylaminoantipyrine and N- acetylaminoantipyrine. However, the rates of appearance of N-formylaminoantipyrine and N-acetylaminoantipyrine were...

Ngày tải lên: 13/08/2014, 11:23

... SNP-induced JNK signal was specifically inhibited by melittin and bee venom. This finding is agreed with other data showing that JNK pathway is important signal in the activation of NF-κB in the ... the NF-κB DNA binding activity induced by LPS or SNPFigure 2 JNK inhibitor suppressed the inhibitory effect of melittin and bee venom on the NF-κB DNA binding activity induced by...

Ngày tải lên: 11/08/2014, 08:22

... fibrosis, causing significant morbidity. There is no therapy for the fibrosis observed in SSc; indeed, the underlying cause of the scarring observed in this disease is unknown. Transforming growth ... signaling pathways may not be suitable targets for selective drug intervention in SSc, examining how individual target genes are selectively induced is likely to provide clues as...

Ngày tải lên: 09/08/2014, 08:22

... The BMP7 staining pattern in mouse knee joint was influenced by disease severity. Mild inflamma- tion (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure ... protein (BMP) signaling in joint homeostasis and disease. Methods Activation of BMP signaling in collagen-induced arthritis as a model of rheumatoid arthritis was studied by immunohist...

Ngày tải lên: 09/08/2014, 13:22

... laminin from human pla- centa that includes laminin-1 (laminin 111), 2 (laminin 211), 6 (laminin 311), 8 (laminin 411), 10 (laminin 511) isoforms, and (3) affinity purified α2 chain-containing laminin ... on dishes pre-coated with different laminin prep- arations, including (1) laminin from EHS tumours that contains laminin type 1 (laminin 111) isoform, (2) affin- ity purified β1 chain-contai...

Ngày tải lên: 12/08/2014, 16:20

... by physically tethering mature virions to the surface of infected cells. HIV-1 counteracts this restriction by expressing the accessory protein Vpu, yet the mechanism of this antagonism is incompletely ... horseradish peroxidase for ECL-based detection or to Alexa Fluor 700/800 fluorescent dyes for detection by Odyssey Infra- red Imaging System (LI-COR Biosciences) and quantifi - cation...

Ngày tải lên: 13/08/2014, 01:20

Ngày tải lên: 13/08/2014, 20:22

... of stay without aff ecting mortality. Interestingly, they reported a signifi - cant and continuous increase in C-reactive protein levels the days before the occurrence of AF, corroborating previous ... previous fi ndings on the hypothesis of an in ammatory substrate in AF onset [2]. AF is the most signifi cant arrhythmia in the ICU.  e risk to develop AF in the ICU is largely...

Ngày tải lên: 13/08/2014, 21:20