Báo cáo y học: " Biomechanical modulation of collagen fragme

Báo cáo y học: " Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs" doc

... which results in the subsequent production of MMPs and cytokines. Our findings are supported by previous studies which demonstrate the induction of MMPs and cytokines in chondrocyte monolayers and cartilage ... properly cited. Research article Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose cons...

Ngày tải lên : 12/08/2014, 12:20

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Báo cáo y học: "Extracellular localization of galectin-3 has a deleterious role in joint tissues" docx

... production of gal-3 could occur in joints even during OA, and particularly during inflammatory phases. Very often, these phases lead to hyperplasia of the synovium, which may invade the joint space and ... of the inhibitors and vitamin D 3 in combination or not with gal-3. The inhibitors used were KT5720 (inhibitor of protein kinase A; final concentration 2 μM), KT5823 (inhi...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: " Systematic monitoring of needs for care and global outcomes in patients with severe mental illness" ppsx

... Details 1 Department of Psychiatry and Psychology, School for Mental Health and NeuroScience MHeNS, Maastricht University, The Netherlands, 2 Division of Psychological Medicine, Institute of Psychiatry, De ... treatment in the course of routine care and is part of the routine outcome monitoring required by insurers and health authorities in the Nether- lands. The bo...

Ngày tải lên : 11/08/2014, 16:22

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Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets" ppt

... construction of a kinetic model of the TCA cycle and glyoxylate bypass in M. tuberculosis, and we study the likely metabolic conse- quences of inhibiting ICLs and ICD1-kinase. To the best of our knowledge, ... developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of...

Ngày tải lên : 13/08/2014, 23:20

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Báo cáo y học: "The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression" ppt

... having more binding sites available to bind to, which in turn means a greater probability of binding and thus repression. In contrast, the reduced repression of a single pair of overlapping binding ... that affect the degree and specificity of miRNA targeting by examining the effects of both single and multiple miRNAs targeting a gene. In the case of single miRNA targe...

Ngày tải lên : 14/08/2014, 08:20

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Báo cáo y học: " Bystander suppression of collagen-induced arthritis in mice fed ovalbumin" pdf

... of the synovial tissue, synovial-cell proliferation, inflammatory-cell infiltration, and BCII = bovine collagen type II; CII = collagen type II; CIA = collagen- induced arthritis; ELISA = enzyme-linked ... events induced by feeding OVA, i.e. bystander suppression, reduced the severity of arthritis in animals immunized with BCII and OVA. Anti-BCII specific antibody responses an...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis" pptx

... is expressed by a variety of cell types involved in RA, including activated T cells and synoviocytes [8]. These cells, in the pres- ence of cytokines like TNFα and macrophage colony stimulat- ing factor, ... RT-PCR of the enzymes involved in the synthesis of these mediators (cyclooxygenase-2 (COX-2) and inducible Figure 1 Cytokine circulating levels in mice at the end o...

Ngày tải lên : 09/08/2014, 06:23

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Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen" ppt

... Steinbeck MJ: Chlorination of pyridinium compounds. Possible role of hypochlorite, N-chloramines, and chlorine in the oxidation of pyridinoline cross-links of articular cartilage collagen type ... A, alanine; L, leucine; T, threonine; Y, tyrosine; εACA, ε-aminohexanoic acid-lysine-lysine- tyrosine-glycine-OH. b Absorbance at 405 nm in ELISA tested with affinity-purified mAbs...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt

... percentage increase in diameter from baseline. After 10 min, a second scan at rest was performed and then nitroglycerin was administered (400 μg sublingual); 5 min later a final scan was taken in order ... relapsing inflammation. Introduction Behçet's disease (BD) is a relapsing systemic inflammatory condition of unknown aetiology that is more prevalent in cer- tain geographica...

Ngày tải lên : 09/08/2014, 10:21

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Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx

... degradation of multi-ubiquitinated proteins [19]. It maintains cell homeostasis by promoting clearance of damaged or improperly folded proteins and degrades key components involved in the cell cycle and ... [21]. Conclusions By altering the binding of at least two transcription fac- tors, c-Jun and SP1, PI results in increased production of MMP-1 and decreased synthesis o...

Ngày tải lên : 12/08/2014, 12:20

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