Báo cáo y học: " Arthritis: where are the T cells" ppt

... whether the recipients received FTY720 or not.  e number of T cells in the secondary lymphatic organs and the titers of IgG1 antibodies against proteo glycan were similar in the FTY720-treated ... [4]. Although interesting and provocative, these data do not rule out the possibility that T cells in the joint are required for development of proteoglycan-induced arthriti...

Ngày tải lên: 12/08/2014, 12:20

... reviewing the safety data at the Week-24 database lock. The relatively small patient populations studied in these trials makes it difficult to assess the safety of TNF-alphas blocking agents in asthma. ... data from this two-year study (DARTT trial) indicated that there was "no measurable disease during the ragweed sea- son in any of the study groups making it impossible to m...

Ngày tải lên: 08/08/2014, 21:20

... [28] may con- tribute to this relatively enhanced peripheral Th2 activity in RA patients compared to healthy controls. The reduced capacity of Th2 cells to migrate to the arthritic sites could subsequently ... could subsequently facilitate the presence of these cells in the peripheral blood and their absence in the joint [34]. The present study suggests that the chronic immune r...

Ngày tải lên: 09/08/2014, 01:23

... initiated ART more than 4 years before blood sampling for the present study and therefore are here included in the ART-treated cohort. Six of the ART- treated individuals (ART01, ART02, ART03, ART04, ART05 ... and the role of the immune sys- tem is less relevant. Finally, we characterized the immune response of 6 ART-treated patients who interrupted the assumption of ART inves...

Ngày tải lên: 10/08/2014, 05:21

... (rat) [NM_207604] Forward AGAACCTTACTCATGTCCCAAAAGAC 79 60 Reverse AGATCAGATATGGAGTTTTGAGACAGACT tlr7 (rat) [NM_001097582] Forward GTTTTACGTCTACACAGTAACTCTCTTCA 75 60 Reverse TTCCTGGAGGTTGCTCATGTTTT tlr8 (rat) [NM_001101009] Forward ... probably the key TLR in synovium in arthritis, whether triggering of the key TLR directly affects arthritis severity and how the key TLR in synovio- cyt...

Ngày tải lên: 12/08/2014, 17:22

... serpin-protease complex, the protease remains covalently linked to the serpin, the enzyme being trapped at the acyl-intermediate stage of the catalytic cycle. Structural comparisons show that the protease ... however, that purified CmPS did not affect insect survival [30]. Together, these data suggest that rather than directly inter- acting with the pathogen, plant serpins, like...

Ngày tải lên: 14/08/2014, 16:21

... from the second study that ‘everything is also phosphorylated everywhere’. In fact, the data tell a much richer and more subtle story, one that is likely to take the next decade or two to unravel. ... although the efficiency and accuracy of this fractionation is not indicated in the paper. Coverage extends from the autophosphorylation of EGFR that initiates the pathway through t...

Ngày tải lên: 14/08/2014, 17:22

... memory T cells. 8 Lastly, both groups erred by not fully understanding the complexity of the system, and it is with a number of recent reports that clarity emerges. Two CD8 cell memory subsets have ... direct the virus to the central compartment. Both groups transferred CD8 T CM cells, and for this reason they agreed that CD8 memory cells survive indefinitely. However, neither gro...

Ngày tải lên: 08/08/2014, 21:20

... out the analysis by flow cytometry. YA, NH and JW evaluated patients’ data. TP and NH drafted the manuscript. All authors read and approved the final manuscript. Competing interests The authors ... University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand. Authors’ contributions All authors contributed to the design of the study, and to the acquisition and interpretation of...

Ngày tải lên: 12/08/2014, 15:22

... SLE patients suggests that at least the latter mechanism is defective, either because there are too many memo ry T cells or they are refractory to RA inhibition. Interestingly, the CD25 - Tregs ... USA. Authors’ contributions ES and LM had full access to all of the data in the study and took responsibility for the integrity of the data as well as for the preparation of th...

Ngày tải lên: 12/08/2014, 17:22