Báo cáo y học: "Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis" ppt

... tetra- cycline derivatives (minocycline, doxycycline, tetracy- cline, and chlortetracycline) for their potential to inhibit PAD4 activity. Chlortetracycline was identifi ed as the most potent inhibitor ... protein [7]. Abstract Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is importa...

Ngày tải lên: 12/08/2014, 12:20

... investigative methods including MRI and electrodiagnostic studies, to objectively identify the cause of pain and other symptoms. [5,6] Although not a universal finding, stiffness of the neck and shoulders ... years. [11] Their findings were confirmed by Tomlinson et al in a follow-up study on the same cohort, 7.5 years later. [9] Existing data suggest that neck stiffness in WA...

Ngày tải lên: 10/08/2014, 10:20

... mice ZIA joints. Interestingly, synovial lining cells, endothelial cells, and sublining nonlymphoid mononuclear cells expressed MMP- 2 in the ZIA synovium. Consistent with these results, in methylated ... MMP-9, and MMP-13) are detected in RA compared with osteoarthritis synovial fluid [20]. In the RA synovium, MMP-2 is expressed in the lining and sublining layers, in...

Ngày tải lên: 09/08/2014, 08:22

... the frequency of different species and strains in the samples that were examined. The analysis of the electrophoresis data pointed out diversity between the samples and the strains that were identified in ... to detach the cells. The trypsin has been inactivated by using FBS (Invitrogen, 10106-169, California) and cells were centrifuged at 1,200 rpm for 10 min. The...

Ngày tải lên: 10/08/2014, 09:22

... Analysis The statistical analysis included 1 and 2-way MANCOVAs with age as covariate (three analyses in total), in order to test for differences in the results of the psychophysiologi- cal testing ... (MRI) may provide a detailed image of brain lesions, in many instances their findings are in contrast to the clinical picture [3]. Short Latency Somato- sensory Evoked Pot...

Ngày tải lên: 08/08/2014, 20:23

... assessed for perforin and granzyme B expression by flow cytometry. Overall, NK cytolytic activity was significantly lower in patients with sJRA than in other JRA patients and controls. In a subgroup ... certainly the most distinct clinical subtype of the disease. In contrast to patients with pauciarticular and polyarticular JRA, in whom the joint disease usually oversh...

Ngày tải lên: 09/08/2014, 06:22

... decreased 3 years after diagnosis and insti- tuted DMARD therapy – but rather, on the contrary, had increased. We think this observation is interesting, but it needs further scrutiny in future ... course/outcome and therapy response, in order to allow rational individually tailored therapy regimens. Furthermore, the high direct costs to society for biological agents place fur-...

Ngày tải lên: 09/08/2014, 10:23

... more supinated foot and optimise gait efficiency [1]. The last shape was measured by bisecting the heel and forefoot areas on the shoe sole, and then measuring the angular difference between the ... to significant intra-rater and inter-rater reliability with the exception of upper wear pattern and outsole wear pattern for intra-rater reliability for rater 2 and int...

Ngày tải lên: 10/08/2014, 21:23

... tissues; VIN: vinorelbine; GEM: gemcitabine Caspase-3 induction determined by flow cytometry in human cancer cell lines in the absence (RPMI) or presence of carbo-platin (CARB), vinorelbine (VIN) and ... investiga- tion. CM and ARR carried out the LIFE/DEAD-assay and 2-pho- ton microscopy. PZ was involved in the design of the study, evaluation of the results and cove...

Ngày tải lên: 12/08/2014, 15:20

... lungs. Few of these Lin- PCs migrated into the airspaces (approximately 3.1% of all the cells remaining in the lung), therefore approxi- mately 14.6% of the initially infused Lin- PCs homed to lung ... then fixed in 10% formalin for more than 24 hours and each lung was cut into five slices for paraffin embedment. Flow cytometric analysis Flow cytometric analysis was performe...

Ngày tải lên: 12/08/2014, 15:21