Báo cáo y học: "Do we need new autoantibodies in lupus" docx

... mimicry [8] to toll-like receptor binding [9] to autoantibody immune complexes stimulating interferon, a key cytokine in the pathogenesis of SLE [10].  us, autoantibodies are especially useful ... anti-Sm fall into this category in that they are exclusively, or virtually exclusively, found in the sera of persons with SLE, but only among a fraction of these patients (reviewed in [5]). Antibodies ... useful if they are helpful in eliminating or establishing the diagnosis, parsing patients in terms of prognosis or risk, or elucidating the underlying mecha-nisms of the disease. In a recent...

Báo cáo y học: "Do we need a critical care ultrasound certification program? Implications from an Australian medical-legal perspective"

... ultrasonography In order to avoid incurring liability while performing critical care ultrasound, intensivists should ensure they are properly trained and competent in the procedure.  e best way to ... body that is well-recognized and widely accepted in Australia and New Zealand, the Australasian Society of Ultrasound in Medicine.ConclusionMedical practitioners owe a duty of care, arising ... smear examination was carried out, the pathology laboratory incorrectly reported the  ndings to be ‘mild squamous atypical cells possibly due to in ammation’ rather than CIN3/micro-invasive...

Báo cáo y học: "Do we use the appropriate controls for the identification of informative methylation markers for early cancer detection" doc

... breast tumorsthat showed no or low methylation in normal individuals. Notably, these lociwere also frequently hypermethylated in normal tissues adjacent to thetumors. Hypermethylation of tumorsuppressor ... different tumor types,including breast cancers [8-10].Examining normal breast cells fromhealthy individuals and cells frombreast tumors, Yan et al. [10] foundhypermethylated loci in breast tumorsthat ... located 5’ to guanines, knownas CpG dinucleotides. Abnormal changes in methylation patterns found in humancancers include global demethylation ofDNA with simultaneous hypermethyla-tion of CpG-rich...

Báo cáo y học: "Human depression: a new approach in quantitative psychiatry" pdf

... serotonin-2 receptor binding sites in depression and suicide. Biol Psychiatry 1990, 28:215-222.31. Menninger JA, Tabakoff B: Forskolin-stimulated platelet adenylyl cyclase activity is lower in ... measurable by electroencephalogram study of the brain's γ wave synchrony.IntroductionThe need for a deep, radical turning point in the world ofpsychiatry is rapidly growing. Present ... potential new pathway that mayincrease our understanding of psychiatric disorders. Thequestion of whether or not changes in 5-hydroxytryptam-ine (5-HT)-serotonin levels are related to changes in...

Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx

... selectively [20]. In that study a highly specific neutralizing antibody againstIL-8 was administered in several types of acuteinflammatory disease, including lipopolysaccharide/IL-1induced arthritis. ... non-inflammatory conditions [2].Most chemokines play a role in inflammatory conditions byinducing integrin activation, chemotaxis, and angiogenesis.Apart from modulating migration directly, ... chemokines canstimulate cells to release (pro)inflammatory mediators suchas cytokines and matrix metalloproteinases [3]. Increasedexpression of inflammatory chemokines has been found in many inflammatory...

Báo cáo y học: " Does monitoring need for care in patients diagnosed with severe mental illness impact on Psychiatric Service Use? Comparison of monitored patients with matched controls" pptx

... care increased in the year after theindexdateislikelytobeaconsequenceoftreatmentinthe CNCM region. We hypothesized that an increase in out-patient care would prevent admission, by deliveringdifferentiated ... waslower in the CNCM region compared to the NN region,both in the year after and in the year before t he indexdate (table 2).Comparing care in the year before and the year afterthe index ... decrease in in-patientdays and the increase in out-patient contacts after theindex date was stronger in the CNCM region than in NN (table 3). However, the difference in in-patient dayswas not...

Báo cáo y học: "The clinical relevance of autoantibodies in scleroderma" pdf

... fre-quency of puffy fingers, small bowel involvement, hypothy-roidism, and a greater risk for reduced survival at 10 years[85], succumbing primarily to pulmonary arterial hyperten-sion. In still ... Reveille92immunoaffinity-purifed RNA polymerase I, II, and III antigen in an enzyme-linked immunosorbent assay. Clin ImmunolImmunopath 1998, 89:71-78.83. Kipnis RJ, Craft J, Hardin JA: The analysis of antinuclear ... rich in NG,NG-dimethylarginine. J Biol Chem 1985, 260:14304-14310.95. Baserga SJ, Yang XD, Steitz JA: An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the proteincommon...

Báo cáo y học: "Microarray analysis of gene expression in lupus" ppt

... controls [18].The microarray assay used (Panorama Cytokine GeneArray membranes; Sigma Genosys, Inc) included375 genes enriched in cytokines, chemokines, cell surface286ably derive from studies ... Uphomolog 1ADAM9 A disintegrin and metalloproteinase domain 9 1.1 (α/β and γ→< 0) UpSERPING1 Serine (or cysteine) proteinase inhibitor (C1 inhibitor) 0.85 Up UpUSP20 Ubiquitin specific protease ... thatwere differentially expressed between SLE and controlPBMC clustered together and were preferentially inducedby a combination of IFN-α and IFN-β. However, two genespreferentially induced by...

Báo cáo y học: "Circadian rhythm and its role in malignancy" docx

... b-catenin, increasing intest inal b-cat enin signal-ing and cell proliferation. Also, increase in small-intestinalmucosa b-catenin in Per2m/mmice is associated wi th anincrease in MYC protein, ... temporally coordinatedphysiology [23-25]. Indirect synchronization is achievedby controlling d aily activity-rest cycles and, as a conse-quence, feeding time. Feeding (or starving) cycles aredominant ... an internal timing system gen-erated by a circadian clock that is synchronized by theday-night cycle [2].Circadian clocksThe circadian timing system proficiently coordinates thephysiology...

Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"

... comparison between the municipality-based centersand the new EMCC indicates that priority codes A andC were used in a different way in the new system, withmore priority A and fewer priority C dispatch ... dispatching codes consisting of priority and chiefcomplaint were used in the feedback system utilized byambulances to send feedback to the EMCC concerningthe patient’s chief complaint and acuity ... is still to answer emer-gency calls immediately, to identify callers’ needs and todispatch the necessary resources wherever and wheneveran emergency need occurs. In 2006, the Finnish govern-ment...

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