Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... bortezomib.
Conclusions: By altering the binding of at least two transcription factors, c-Jun and SP1, proteasome inhibition results
in increased production of MMP-1 and decreased synthesis of type I collagen in human ... recently reported that proteasome inhibition
(PI) profoundly modifies the phenotype of human dermal
fibroblasts by reducing type I c...
Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt
... assays show that EKLF favors binding to
the human and murine adult type of b-globin CACC
element over the CACC elements in the murine fetal bh1-
globin, human c-globin or the erythropoietin receptor
(EpoR) ... factor binding at HS3 initiates the process,
allowing the spreading of open chromatin, binding of other
trans-acting factors throughout the LCR, and loopin...
Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... col-
lagenase] and MMP-13) have the unique ability to cleave
the triple helix of collagen, thereby allowing the chains to
unwind; the chains then become susceptible to further
degradation by other MMPs. ... JA, Benbow U, Vincenti MP, Sporn MB, Brinck-
erhoff CE: A synthetic triterpenoid selectively inhibits the
induction of matrix metalloproteinases 1 and 13 by inflam...
![Báo cáo y học: " Transcriptional regulation of metastatic [Id]entity by KLF17" pdf](https://media.store123doc.com/images/document/2014_08/10/medium_wuv1407590453.jpg)
Báo cáo y học: " Transcriptional regulation of metastatic [Id]entity by KLF17" pdf
... might play a role in the regulation of
invasion and metastasis in different cancer types.
Figure 1
Regulation of ID1 expression by KLF17. ID1 transcription is suppressed by KLF17 binding to the ID1 ... motifs using Scansite [23]
predicts a high-stringency target site for phosphorylation
by protein kinase C-ε (PKCε) within the amino-terminal
region of KLF17. Give...
Báo cáo y học: "Transcriptional regulation of lung development: emergence of specificity" pdf
... belonging to the Hox gene cluster in the mes-
enchyme of the developing lung [38]. Such changes have
the potential to alter the inductive or instructive role of the
mesenchyme, thereby affecting ... research
http://respiratory-research.com/content/1/2/109
genetically related to hedgehog in Drosophila, which is
involved in the patterning of a number of body parts i...
Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
... gp130, Tyr985
of the leptin receptor and Tyr401 of the erythropoietin
receptor, Tyr729 of the granulocyte colony-stimulating factor
(G-CSF) receptor, Tyr800 of the IL-12 receptor and Tyr985
of the ... & Therapy June 2005 Vol 7 No 3 Yoshimura et al.
Abstract
Immune and inflammatory systems are controlled by multiple
cytokines, including interleukins and interf...
Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... high and constant level of c-Myc. Also, the contribution
of Ras/Raf/ERK prevented the rapid degradation of c-Myc by
phosphorylation of the serine 62 residue in the N-terminal of c-
Myc [24]. They ... and
8a). However, inhibition of c-Myc transcriptional activity by
10058-F4 in the presence TGF1 resulted in suppression of
the mitogenic effect of T...
Báo cáo y học: " Epidemiologic heterogeneity of common mood and anxiety disorders over the lifecourse in the general population: a systematic review" ppsx
... symptoms and symptoms
characterized by appetite increase and weight gain, and
four other subtypes of varying symptom severity [22].
Similarly, two twins studies using latent class analysis,
including ... were dis-
tinguished by the symptom severity of their social phobia
[27]. In contrast, a study using principal components
analysis found that the number of social fears...
Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... effective to inhibit the activity of the enzyme (data
not shown).
NDGA is known to inhibit the activity of lipoxygenase
by binding to the reduced form (Fe
2+
)oftheenzyme
thereby keeping it inactive ... ACTH on
the transcript was inhibited by actinomycin D and
enhanced by cycloheximide [32]. Given the obligatory role
of the protein in the activation of steroi...