Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx

... bortezomib. Conclusions: By altering the binding of at least two transcription factors, c-Jun and SP1, proteasome inhibition results in increased production of MMP-1 and decreased synthesis of type I collagen in human ... recently reported that proteasome inhibition (PI) profoundly modifies the phenotype of human dermal fibroblasts by reducing type I c...

Ngày tải lên: 12/08/2014, 12:20

... assays show that EKLF favors binding to the human and murine adult type of b-globin CACC element over the CACC elements in the murine fetal bh1- globin, human c-globin or the erythropoietin receptor (EpoR) ... factor binding at HS3 initiates the process, allowing the spreading of open chromatin, binding of other trans-acting factors throughout the LCR, and loopin...

Ngày tải lên: 08/03/2014, 22:20

... col- lagenase] and MMP-13) have the unique ability to cleave the triple helix of collagen, thereby allowing the chains to unwind; the chains then become susceptible to further degradation by other MMPs. ... JA, Benbow U, Vincenti MP, Sporn MB, Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflam...

Ngày tải lên: 09/08/2014, 03:24

... might play a role in the regulation of invasion and metastasis in different cancer types. Figure 1 Regulation of ID1 expression by KLF17. ID1 transcription is suppressed by KLF17 binding to the ID1 ... motifs using Scansite [23] predicts a high-stringency target site for phosphorylation by protein kinase C-ε (PKCε) within the amino-terminal region of KLF17. Give...

Ngày tải lên: 09/08/2014, 20:20

... belonging to the Hox gene cluster in the mes- enchyme of the developing lung [38]. Such changes have the potential to alter the inductive or instructive role of the mesenchyme, thereby affecting ... research http://respiratory-research.com/content/1/2/109 genetically related to hedgehog in Drosophila, which is involved in the patterning of a number of body parts i...

Ngày tải lên: 12/08/2014, 18:20

... gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietin receptor, Tyr729 of the granulocyte colony-stimulating factor (G-CSF) receptor, Tyr800 of the IL-12 receptor and Tyr985 of the ... & Therapy June 2005 Vol 7 No 3 Yoshimura et al. Abstract Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interf...

Ngày tải lên: 09/08/2014, 06:23

... high and constant level of c-Myc. Also, the contribution of Ras/Raf/ERK prevented the rapid degradation of c-Myc by phosphorylation of the serine 62 residue in the N-terminal of c- Myc [24]. They ... and 8a). However, inhibition of c-Myc transcriptional activity by 10058-F4 in the presence TGF1 resulted in suppression of the mitogenic effect of T...

Ngày tải lên: 09/08/2014, 01:22

... symptoms and symptoms characterized by appetite increase and weight gain, and four other subtypes of varying symptom severity [22]. Similarly, two twins studies using latent class analysis, including ... were dis- tinguished by the symptom severity of their social phobia [27]. In contrast, a study using principal components analysis found that the number of social fears...

Ngày tải lên: 11/08/2014, 17:20

... effective to inhibit the activity of the enzyme (data not shown). NDGA is known to inhibit the activity of lipoxygenase by binding to the reduced form (Fe 2+ )oftheenzyme thereby keeping it inactive ... ACTH on the transcript was inhibited by actinomycin D and enhanced by cycloheximide [32]. Given the obligatory role of the protein in the activation of steroi...

Ngày tải lên: 08/03/2014, 09:20