Báo cáo y học: "A1298C polymorphism in the MTHFR gene predis

Báo cáo y học: "A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis" ppt

... MTX toxicity and hyperhomocysteinemia [9]. A common C677T polymorphism in the gene coding for the MTHFR enzyme has been found to be a new can- didate genetic risk factor for CV disease in the general population ... seen in single heterozygotes for the C677T variant [11]. Interestingly, a recent study has disclosed an association of the A1298C polymorphism in the...

Ngày tải lên : 12/08/2014, 12:20

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Báo cáo y học: "Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts" pps

... participated in the analysis of the study and in the writing of the manuscript. BC and JM participated in the design of the study and in the writing of the manuscript. All authors read and approved the ... approximately 30% of RA FLSs as determined by Annexin V staining /TO- PRO-3 uptake. This technique allows investigators to distinguish early apoptotic cells (Ann...

Ngày tải lên : 09/08/2014, 10:22

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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf

... accessible autolytic sites in chymotrypsinogen. The molecular model (top) displays bovine chymotrypsinogen, the schematic diagram (bottom) shows rat D-chymotrypsinogen. Domain 1 is cyan, domain 2 is green, ... trypsinogen propeptide instead of the Cys1–Cys122-linked wild-type chymotrypsinogen peptide. D-Chymotrypsinogen also contained a Cys122!Ser substitution. The activator enter...

Ngày tải lên : 22/02/2014, 07:20

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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

... transformation, the time domain data were multi- plied by shifted sine functions (COSY) or lorentz -to- gauss windows (NOESY, TOCSY) in the direct dimension, and by shifted sine or sine square functions in the ... containing the pure peptide was lyophilized twice and the purity assessed by a MALDI-TOF analysis using a Hewlett Packard G2025A LD-TOF system mass spectro- meter and...

Ngày tải lên : 08/03/2014, 09:20

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Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efﬁciency of carboxypeptidase Y pot

... 2002 designed to maintain hydrophobicity and Gly, Ser, Asp and His mutants to provide hydrophilicity. The catalytic roles of Cys341 in carboxypeptidase Y are examined by comparing the kinetic parameters ... thiol group (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1...

Ngày tải lên : 08/03/2014, 23:20

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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc

... shown to play major roles in the inflammatory process, anti-inflammatory mediators as well as proinflammatory ones. The cytokine interleukin-10 (IL-10) has been in focus for many years in autoimmune ... are required in order to induce disease [10,20]. No data have been reported on the role of cytokines in RP, either in patients or in the corresponding animal models....

Ngày tải lên : 09/08/2014, 01:24

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Báo cáo y học: "Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case– control study" docx

... 50:1117-1121. 11. Barton A, Bowes J, Eyre S, Symmons D, Worthington J, Silman A: Investigation of polymorphisms in the PADI4 gene in deter- mining severity of inflammatory polyarthritis. Ann Rheum ... demonstrated. Introduction Peptidylarginine deiminases (EC 3.5.3.15) are enzymes involved in the post-translational deimination of protein-bound arginine to citrulline [1]. Five di...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Primary osteosarcoma of the urinary bladder treated with external radiotherapy in a patient with a history of transitional cell carcinoma: a case report" pptx

... six months. The tumor tends to be locally aggressive. Dis- tant metastases are uncommon and are usually confined to the lung. Recommendations to improve survival have included radical cystectomy with ... patient. HD was involved in patient care and writing supervision. All authors read and approved the final manuscript. Competing interests The authors declare that they have no...

Ngày tải lên : 11/08/2014, 11:23

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Báo cáo y học: " Concomitant homozygosity for the prothrombin gene variant with mild deficiency of antithrombin III in a patient with multiple hepatic infarctions: a case report" pdf

... massive pulmonary embolism [9]. In contrast to this, two homozygotes had no thrombosis, suggesting that the mutation alone is less risky than other genetic risk factors [6]. Visceral vein thrombosis ... because of the richly anasta- mosing collateral arterial supply, and the dual blood supply from the portal vein and hepatic artery. In this case, there was portal hypertensio...

Ngày tải lên : 11/08/2014, 12:20

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Báo cáo y học: " Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD)" pdf

... Mutations in the DNAI1 gene , encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive ... the randomization of body symmetry (for the clarity we will refer to PCD families without s.i. as CDO, ciliary dyskinesia only). The complex PCD pheno...

Ngày tải lên : 12/08/2014, 13:22

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