Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx

... Open Access B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy Diego Catalán 1 , ... coordination of the study. AMK participated in the conception and design of the study and critically revised the manuscript. JCA par...

Ngày tải lên: 12/08/2014, 12:20

... stimulation. Recent therapeutic interventions such as anti-TNF-α and inter- leukin-1 inhibition show the importance of cytokines in RA [16]. Induction of proinflammatory cytokines via cross-linking of FcγR by ... vaccination in healthy individuals during the time interval when antibodies and anti- gen form circulating ICs [4]. RF-producing B cells are present in t...

Ngày tải lên: 09/08/2014, 07:20

... iodine and the levels of amylopectin and amylose were determined by amyloglucosidase assays (Roche). In vitro assay of GBSSI activity This assay is fully described in both [18] and [22]. Brie y, 50 ... rate of amylopectin synthesis. The increase in crystallinity wit- nessed during these first 12 h is in line with the high rates observed for amylopectin synthesis. H...

Ngày tải lên: 22/02/2014, 07:20

... to the mechanism underlying protein stability at the amino-acid level. The molecular mechanisms underlying protein maturation, folding, and stability in bacterial cytochromes c are beginning ... together with the results from rapidly increasing X-ray crystal and NMR analyses, have stimulated mutagenesis studies, which con- tribute to the understanding of the mechanis...

Ngày tải lên: 24/03/2014, 03:21

... clinical investigation and estab- lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies by Holman and Kunkel [1] and of rheumatoid factor by ... upstream of the current treatment regimens employing cytokine blockage and that may be well suitable for a subset of patients. Identifying the mechanisms by whi...

Ngày tải lên: 09/08/2014, 01:21

... of exocrine gland [66]. In patients with pSS and recurrent or persistent swelling of the major salivary glands, the lymphocytic lesions of the involved glands often contain massive lymphoid infiltrates ... that memory B cells with less migratory capacity remain in the blood as a result of the selective migration and retention of CXCR4 + CXCR5 + memory B cells...

Ngày tải lên: 09/08/2014, 10:20

... [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects. An important immunoregulatory cytokine produced by B cells is IL-10, which ... be effective in human SLE. Formation of ectopic GCs has been identified in the kidneys of patients with SLE, in the salivary glands of patients with Sjögren...

Ngày tải lên: 09/08/2014, 14:22

... report on the GDP-6-deoxy- D -talose biosynthetic pathway and the role of GDP-4-keto-6-deoxy- D -mannose reductase in the synthesis of GDP-6-deoxy- D -talose. Keywords: Actinobacillus actinomycetemcomitans;6-deoxy- talose; ... in the clusters responsible for synthesizing the SPAs in other serotypes of A. actinomycetemcomitans. The biosynthetic pathway for GDP-6-deoxy...

Ngày tải lên: 17/03/2014, 10:20

... the weekly dose was calculated by divid- ing the IV dose by the number of weeks in the dos- ing interval. This was then rounded off to the nearest even number of unit dose vials as the weekly ... With the exception of the two infants, the other patients selected com- binations of these variables with which they were quite happy and on which they continu...

Ngày tải lên: 08/08/2014, 20:23

... THR0921 resulted in reduced production of TNF-α, IL-1β, and INF-γ from isolated spleen cells induced by LPS. As the involvement of each of these cytokines in the pathogenesis of arthritis is well Figure ... derived from any of the groups (data not shown). Cytokine expression in ankle joints To investigate the effect of oral administration of THR0921 a...

Ngày tải lên: 09/08/2014, 07:20