Báo cáo y học: "Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise" pdf

... of RAGE by multiple ligands including S100 protein, high-mobility group box chromosomal protein 1 and AGEs (complex and specific AGEs) in OA chondrocytes and synovi- ocytes results in increased ... p38-MAPK and JNK activation. In addition, EGCG inhibited the phosphorylating activity of IKKβ kinase in an in vitro activity assay and EGCG inhibited the AGE- mediated activatio...

Ngày tải lên: 09/08/2014, 14:20

... Haqqi TM: Green tea polyphenol epigallocatechin- 3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic ... Haqqi TM: Green tea polyphenol epigallocatechin- 3-gallate (EGCG) di erentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in...

Ngày tải lên: 12/08/2014, 12:20

... produced predominantly by activated macrophages and lymphocytes mediate many inflamma- tory processes [49]. These proinflammatory cytokines include interferon-γ (IFN-γ), interleukin-1 (IL-1), tumour necrosis ... (Milano, Italy), and it was defined by the producer as having a polyphenolic content of 75 ± 5% with the major constit- uent being epigallocatechin- 3-gallate at 62% and the...

Ngày tải lên: 12/08/2014, 18:21

... Recently, it was demonstrated that tea catechins directly bind to DNA and preferentially bind to poly(A), poly(U), and poly(AU) in RNA [42]. It will be interesting to investigate if green tea polyphenols ... Corresponding authors Abstract Background: Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs...

Ngày tải lên: 11/08/2014, 08:21

... skin cancers. Topical treatment of the mouse skin with EGCG or oral administration of GTPs in drinking water of mice signifi cantly inhibited UVB radiation-induced in amma- tory responses, and ... genicity of  17, a major eff ector cell driving in amma tion and auto- immunity [8]. In the photocarcino genesis model, UV radiation-induced in ammation has been implicated in nonm...

Ngày tải lên: 12/08/2014, 17:22

... vitro and in vivo studies demonstrated that polyphenols from green tea were anti-carcinogenic by inducing apoptosis and inhibiting cell-growth, cyclin- dependent kinase inhibitor and urokinase ... pharmacokinetics of polyphenols in green tea were conducted [7,8]. The evidence suggests that ingested polyphenols and their metabolites play a role in the action against gastroint...

Ngày tải lên: 13/08/2014, 15:21

... of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and previous ... contains eight arginine residues within, or close to, its active site that may be involved in catalysis. Arg258 has already been shown by structural and mutagenesis studies to bind the 5-c...

Ngày tải lên: 18/03/2014, 01:20

... Interleukin-13 Inhibition Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are cytokines that play a role in allergic inflammation by inducing Th2 responses. Interleukin-4Rα is the signaling component ... Clinical features Type α High cytokine & cytokine release syndrome Symptoms will depend on the cytokine or cytokine being targeted e.g., high levels of INF-α may cause 'flu-like...

Ngày tải lên: 08/08/2014, 21:20

... rendering it practical for use in everyday practice. According to the developers, the instrument can accurately and reliably identify symptoms of anxiety in older people even, and espe- cially, in ... R: Screening for depression and anxiety disorders in primary care patients. Depress Anxiety 2006, 24:455-60. 12. Peveler R, Kilkenny L, Kinmonth AL: Medically unexplained physical...

Ngày tải lên: 08/08/2014, 23:21

... stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and the development of OA through a mechanism involving the acceleration of chondrocyte senescence. ... a tendency to maintain the chondrocyte telomere length and proteoglycan remaining in the cartilage explants, suggesting that oxidative stress induces chondrocyte telom...

Ngày tải lên: 09/08/2014, 06:22