Báo cáo y học: "Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes" potx

... Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes Arthritis Research & Therapy 2010, ... and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes Sanna Rosengr...

Ngày tải lên: 12/08/2014, 12:20

... Itoh J, Kyogoku M, Ronnelid J, Miyazono K, Heldin CH, et al.: Enhanced expres- sion of transforming growth factor- beta s and transforming growth factor- beta type II receptor in the synovial tissues ... stimulated by the inflammatory microenvironment [2], are major compo- nents of the pannus and contribute to joint destruction by secretion of pro -inflammatory cytoki...

Ngày tải lên: 09/08/2014, 10:20

... 9 proinflammatory cytokines, such as TNF-a and IL-1b, and other mediators, such as myeloperoxidase and reac- tive oxygen species (ROS), causing the inflammatory activation of the mucosal immune system ... may cause colitis by lipid peroxi- dation and enterobacterial proliferation, which may deteriorate the colitis by regulating proinflammatory cytokines via TLR-4-linked NF-B ac...

Ngày tải lên: 11/08/2014, 08:22

... includ- ing inflammatory response and host resistance to patho- gens [34,41]. TNF-a may activate nuclear factor- kB (NF-kB) by inducing the phosphorylation and degrada- tion of inhibitory factor- kB ... cytokine/chemokine bio- synthesis may be interrupted by the viral components. Cytokines and chemokines generally function in an autocrine (on the pro ducing cell itself) or par...

Ngày tải lên: 12/08/2014, 02:20

... phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia Adetola B Adesida, Lisa M Grady, Wasim S Khan and Timothy ... proteoglycan (total glycosaminoglycan) over 14 days and deposited a collagen II- rich matrix. The gene expression of matrix-associated proteoglycans (biglycan and fibromodulin) wa...

Ngày tải lên: 09/08/2014, 07:20

... °C. The carboxymethyl dextran matrix of the sensor chip was activated by a 30-lL injection of the mixture of 0.2 M 1-ethyl-3-[(3-dimethylamino)propyl]carbodiimide and 0.05 M N-hydroxysuccinimide ... PheRS was shown by the gel- shift assay and surface plasmon resonance technique. High stability of both novel ternary and quaternary complexes of eEF1AÆGDP, [eEF1AÆGDPÆtRNA] and [eEF1A...

Ngày tải lên: 21/02/2014, 15:20

... chronic inflammatory disease characterized by the infiltration of the synovial membrane with monocytes/T cells, by the proliferation of synovial lining cells and by the production of proinflammatory ... evaluated the expression and function of AP-1, NF-κB and Egr-1 in human RA synoviocytes by RT-PCR and by immunocytochemistry after induction with IL-1, TNF-α and IL-17 al...

Ngày tải lên: 09/08/2014, 01:23

... promoting proteoglycan synthesis by chondrocytes. By contrast, 2.7 nM R 3 IGF-1 significantly stimulated total proteoglycan synthesis, by 45% over that by unstimulated cells. Since IGF-1 and R 3 IGF-1 ... restoration of proteoglycan synthesis by human OA chondrocytes. IGFBPs secreted by human OA cartilage or cultured chondrocytes were analyzed by western ligand blot. Th...

Ngày tải lên: 09/08/2014, 01:23

... study and analysed the data. JJI, BLK, YC, and SPH designed the study. AN contributed to the phage display experimental design. YC contributed to the cloning and expression of the TNFRs and riboprobes. ... loading dye and heated for 10 min at 95°C. Samples were then run on a 10% SDS gel and probed with an anti-His antibody. Immunohistochemistry and histology L4/L5 DRGs were remo...

Ngày tải lên: 09/08/2014, 06:23

... of hydroxylases that are crucial for collagen fibre formation such as prolyl 4-hydroxylase and pro- collagen lysyl-hydroxylase [45-47]. Through these actions, HIF1α affects the rate of synthesis ... of key genes expressed by chondrocytes, notably the transcription factors SOX5, SOX6 and SOX9. These find- ings show that oxygen tension has an important role in regulat- ing the synthesi...

Ngày tải lên: 09/08/2014, 10:20