Báo cáo y học: "A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis" pps

... A crucial role for tumor necrosis factor recep- tor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis Arthritis Research & Therapy 2 010 , 12 :R 61 Arntz ... provided the original work is properly cited. Research article A crucial role for tumor necrosis factor receptor 1 in synovial...

Ngày tải lên: 12/08/2014, 12:20

... seen only at day 0 (*P < 0.05). (a) (b) (c) 10 10 0 10 00 10 000 10 10 0 10 00 10 000 10 10 0 10 00 10 000 10 10 0 10 00 10 000 10 10 0 10 00 10 000 10 10 0 10 00 10 000 lpr -/- day 0 Titer lpr -/- day 20 lpr ... proinflammatory cytokines in joints Since cytokines such as TNF-α and IL-6 are critical media- tors of inflammation, we investigated the effect of F...

Ngày tải lên: 09/08/2014, 01:23

... equity in the company. Zirus, Inc. holds intellectual patents to ADAM10. All other authors declare no competing interests. Received: 11 November 2 010 Accepted: 11 May 2 011 Published: 11 May 2 011 References 1. ... ontains a disintegrin domain, an EGF- like domain, a cysteine-rich domain, a transmembrane domain, and a cytoplasmic domain [13 ]. ADAM10 is required in NOTCH signal...

Ngày tải lên: 13/08/2014, 01:20

... cytokines like IL-6 and IL -11 that lead to gp130 homodimerization, two different epitopes of gp130 are involved in ligand binding: the Ig-like domain and the CBM [9 11 ]. In the case of LIF-induced ... of gp130c, the amino-acid residues following the Jak binding sites (box1 and box2, gray boxes) were replaced by the strongly and specifically STAT1-activating motif YDKP...

Ngày tải lên: 18/03/2014, 01:20

... by alanine, either individually, resulting in HspH(I133A) and HspH(I135A), or simultaneously, leading to HspH(II133 ,13 5AA). Finally, we searched for the minimal fragment required for dimer formation. ... encoding the isolated a-crystallin domain or the a-crystallin domain including either the N-terminal region or the C-terminal extension were constructed in a similar man...

Ngày tải lên: 31/03/2014, 21:21

... PMN PMN + FLS CD11b CD18 ICAM -1 CD11b CD18 ICAM -1 CD11b CD18 ICAM -1 FLS + PMN * * * The augmentation of IP -10 production was dependent on an interaction between synovial FLSs and leukocytes; indi- vidually, ... [16 ,17 ]. IP -10 , a CXCR3 ligand, may be expressed in the inflamed synovium of RA, and appears to play an important role in the recruitment of Th1-type cell...

Ngày tải lên: 09/08/2014, 01:21

... NR3C1 (CGC points 16 .5, CGC ranking 3, manual rating 2), SPINK5 (CGC points 14 .2, CGC ranking 4, manual rating 3), IK (CGC points 14 .1, CGC rank- ing 5, manual rating 3) and CD14 (CGC points 12 .8, ... explicitly mentioned in the text investigated. In the paper describing Olofsson's findings, the authors stated that they found the candidate gene approach distracting,...

Ngày tải lên: 09/08/2014, 06:22

... allele- specific tumor copy numbers from a single pair of tumor- normal genotyping microarrays. BMC Bioinformatics 2 010 , 11 :245. Yau et al. Genome Biology 2 010 , 11 :R92 http://genomebiology.com/content /11 /9/R92 Page ... base- line uncertainty for polyploid tumors have recently been developed [17 , 21] but these are only effective in the absence of normal DNA contamination a...

Ngày tải lên: 09/08/2014, 22:23

... (DCC) proteins (SDC2, SDC3, DPY27, DPY28 and MIX1) and other X- Cheng et al . Genome Biology 2 011 , 12 :R15 http://genomebiology.com/2 011 /12 /2/R15 Page 13 of 18 sensitivity and specificity can be ... study. CC and KKY performed the full analysis. CC, KKY, KYY, RA, JR, CS and MG wrote the manuscript. Received: 21 December 2 010 Revised: 26 January 2 011 Accepted: 16 Fe...

Ngày tải lên: 09/08/2014, 22:23

... additional 24 h incubation and stained for CD11c, CD13, CD14, CD83 and CD86 and analyzed by flow cytometry. In each case all the isolated floating cells were analyzed without gating and phenotype of ... into T -17 5 flasks and the monocytes adhered for 2.5 h as described in the Methods section. After washing out the non-adherent cells in both systems, the...

Ngày tải lên: 11/08/2014, 10:23