Báo cáo y học: "B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial" docx

... ARTIC LE Open Access B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow -up open-label trial Silvia ... progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months foll...

Ngày tải lên: 12/08/2014, 12:20

... and circulating B cells and on interleukin-6 and BAFF (B -cell activating factor of tumor necrosis factor family). The excellent safety pro le of rituximab in this and other trials warrants ... cells.  e clinical eff ects were paralleled by biological eff ects, including depletion of circulating B cells, and changes in serum levels of interleukin-6 (IL-6) and BAFF (B...

Ngày tải lên: 12/08/2014, 12:20

... necrosis fac- tor-α (TNF-α) and cytokeratin 19 were from Sigma-Aldrich (Saint Quentin Fallavier, France). Cytokeratin 7 was from Bio- genex (Antony, France). Cytokeratins 20 and 903, and CD45 and EnVision ... staining for cytokeratin 7 (a) and cytokeratin 19 (b) and the absence of staining with cytokeratin 20 (c) indicates the specificity of ductal epithelial cell origin. The a...

Ngày tải lên: 09/08/2014, 07:20

... multi-lobulated (hematoxylin and eosin stain; original magnification, × 40). Figure 1 Marked sclerosis and hyalinization in diffuse large B- cell lymphoma (hematoxylin and eosin stain; original magnification, ... underwent a cervical lymph node biopsy (large excision). According to the first biopsy findings, based on hema- toxylin and eosin-stained slides created by co-authors...

Ngày tải lên: 11/08/2014, 00:23

... resulting in an inflammatory state as well as cartilage degradation [14]. As further evi- dence for the role of pro-inflammatory cytokines in RA, anti-tumor necrosis factor-α (anti-TNF-α) and anti-inter- leukin ... decreased the induction of MMP-1 and MMP-13 by IL-1. In human primary chondrocytes, 300 nM CDDO inhibited the induction of these genes by IL-1 to an even greater ex...

Ngày tải lên: 09/08/2014, 01:23

... of such cells. In cutaneous lupus erythematosus, MIG and IP-10 have been found to be significantly upregulated in inflamed skin and to help in the recruitment of plasmacytoid dendritic cells (pDCs), ... of chemokine and IFN scores between SLE and RA patients, and healthy donorsComparison of chemokine and IFN scores between SLE and RA patients, and healthy donors....

Ngày tải lên: 09/08/2014, 13:22

... (Peg-IFN alpha-2a plus ribavirin) and just before starting interferon and ribavirin therapy for chronic HCV infection, at the Hepatology and Gastroenterology Department of the Arnault Tzanck Institute (St Laurent ... The sensitivity and line- arity of the assay were validated for all the genotypes [27]. Genotypes were determined by sequence and phyloge- netic analysis of the 5'...

Ngày tải lên: 13/08/2014, 13:20

... grateful to Jan Lohmann and Markus Schmid for discussion, and Wolfgang Busch, Joffrey Fitz, Stephan Ossowski, Korbinian Schneeberger, and Norman Warthmann for helpful suggestions and critical reading ... tiling array analysis. GZ, SRH, SL, and TS analyzed the data. TS and CKW developed online vis- ualization tools. SL, GZ, GR, and DW wrote the manuscript. All authors read and...

Ngày tải lên: 14/08/2014, 20:22

... Cooperative interaction of nuclear factor-κB- and cis-regulatory enhancer binding pro- tein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol ... arthritis. Annu Rev Immunol 1996, 14:397-440. 2. Andreakos ET, Foxwell BM, Brennan FM, Maini RN, Feldmann M: Cytokines and anti-cytokine biologicals in autoimmunity: present and future....

Ngày tải lên: 09/08/2014, 08:23

... of BLyS and APRIL in a 4-hour signaling assay by using transmembrane activator and CAML interactor (TACI)-transfected Jurkat cells and in a 4-day primary human B -cell proliferation assay. A bead-based ... homo- trimers, and may be present in sera in similar amounts to APRIL and BLyS, we postulate that they may likely play similar biologic roles to BLyS and APRIL in...

Ngày tải lên: 12/08/2014, 12:20