Báo cáo y học: " Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus" doc

... fre- quencies of Th17 and Th1 cells that was found in healthy controls was disrupted in lupus patients. These observ ati ons indicate that the balance of Th17 and Th1 cell responses is dysregulated in SLE, ... of Th17 cells is suppressed by interferon (IFN)-g produced by Th1 cells, suggesting cross-regulation between Th17 and Th1 cells. Thus,...

Ngày tải lên: 12/08/2014, 12:20

... ammatory cytokine production.  is chronic produc- tion of in ammatory cytokines and proteases may lead to thinning of the plaque wall and eventual rupture, which results in exposure of the ... telomere shortening/senescence and cytokines such as TNF [22-24]. Mechanisms of endothelial injury and atherosclerosis in SLE Induction of an imbalance of vascular damage...

Ngày tải lên: 12/08/2014, 15:22

... including cells of the immune system; and it is a master switch in the initiation and perpetuation of inflammatory responses (Figure 1). When the role of TNF and TNF inhibition in systemic lupus ... (green lines) and plays a role in maintaining survival niches for long-lived plasma cells (PlasmaC). Some of these effects are indirect in part, involving cytokines...

Ngày tải lên: 09/08/2014, 10:22

... effi- ciently in high NaCl, and/ or that the dissociation of interacting proteins and DNA by high NaCl and possibly secondary con- formational changes help the binding of anti-RPA antibodies in autoimmune ... sera. We examined whether the binding of DNA to RPA can inter- fere the reactivity of anti-RPA autoantibodies by incubating affinity-purified RPA with ssDNA, dsDNA, or d...

Ngày tải lên: 09/08/2014, 08:22

... to activation-induced cell death. Moreover, these cells are characterized by intracellular storage of the cytolytic proteins perforin and granzyme B and are functionally specialized for cytotoxic activity ... joint involvement and rapid joint progression confirm observations that the frequency of CD4 + CD28 – T cells may correlate with the risk of occurrence of joint erosion...

Ngày tải lên: 09/08/2014, 01:22

... (Department of Dermatology, Venerology and Allergol- ogy, University Hospital Charité, Berlin, Germany), Kerstin Steinbrink (Department of Dermatology, University of Mainz, Germany), Annegret ... overlap syndrome. Mycophenolate mofetil, increasingly applied for the treatment of allograft rejection and kidney involvement in systemic lupus erythematosus, is used in a conside...

Ngày tải lên: 09/08/2014, 13:22

... Register of Criminality at follow-up in July 2007. The crimina l reg- ister has lifetime information about all criminal proceed- ings against everyone residing in Norway. The reported findings are ... description of the offences committed. The offences were classified into violent offences (all offences involving interpersonal aggression and threats, robbery, arson), sexual offences...

Ngày tải lên: 11/08/2014, 15:22

... report of a 44-year-old woman with acquired partial lipodystrophy. To obtain insight into the molecular basis of lipoatrophy in acquired partial lipodystrophy, we examined gene expression in adipose ... JCD performed the analysis and interpretation of mitochon- drial DNA data and JG and MG analyzed the mRNA. FV designed and coordinated the study and was responsible for fin...

Ngày tải lên: 11/08/2014, 21:22

... A decrease in severity and duration reduces costs, which may partly or totally, in the case of a dominant interven- tion, offset the costs of supplementation and also improve quality of life. Adding ... to rehydrate the child from time of admission, episodes of vomiting, use of intravenous fluids during rehydration and the use of unscheduled intravenous fluids during t...

Ngày tải lên: 13/08/2014, 13:20

... result of advocacy by internal and external actors concerned about HIV in Myanmar, increased investment of international resources and increased recognition by the Ministry of Health of the issue. ... country. The operational environment remains difficult to predict. In February 2006, the Ministry of Foreign Affairs, the Min- istry of Home Affairs and the Ministry of N...

Ngày tải lên: 13/08/2014, 13:21