Báo cáo y học: " Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis" doc

... Interferon-? inhibits interleukin-1?-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis Arthritis Research & Therapy ... expres- sion in joints affected by AIA on Day 1. Abundant stain- ing was detected in the synovial lining layer, joint exudate and focal areas of synovial infiltrat...

Ngày tải lên: 12/08/2014, 12:20

... amplification in a 50-µl reaction mixture con- taining 1 U of DynaZyme II DNA polymerase (Finnzymes OY, Espoo, Finland), 5 µl of 10 × PCR Buffer (Finnzymes OY), 0.2 mM of each dNTP, and 15 pmol/µl ... levels Cytokine levels in culture supernatants and SF were mea- sured by cytokine-specific ELISAs. IL-12p40 and IL- 12p70 were measured using matched capture and detection antibody...

Ngày tải lên: 09/08/2014, 06:22

... d by RASF finally cause the destruction of the joint [3]. As loss of integrity of compartment borders in the joint b etween cartilage and SF is a key event in RA, we were interested in analyzing ... in designing the study, in analysis and interpretation of the data and in drafting the manuscript. AKB conceived the study and was responsible for its design and coordina...

Ngày tải lên: 12/08/2014, 12:20

... [4-6]. Airway fibroblasts and myofibroblasts are a primary source of ECM proteins, including fibronectin, in subepithelial fibrosis linked to airway remodeling [7]. Targeting and understanding molecular ... GGT1-cata- lyzed geranylgeranylation are crucial for TGFb1-induced fib ronectin expression in airway fibroblasts. These find- ings are s upported by studies using human fetal...

Ngày tải lên: 12/08/2014, 14:20

... wild-type and trans- genic mice are shown in Fig. 2. Increased cell proliferation and Th1 cytokine production in lymph node cells from transgenic mice The draining axillary and popliteal lymph ... wild-type mouse, and a larger joint (b), show a smooth cartilage surface without any cartilage or bone destruction. (c) The synovial lining layer is composed of flat synovial c...

Ngày tải lên: 09/08/2014, 01:23

... expression increased significantly in R and AR, and blockade of CD28 decreased the Th2 cytokine production, indicating the involvement of CD28 in Th2 cell activation in allergy. It is noteworthy that ... initially shown to selectively induce high levels of IL-10 and IL-4, but is also able to stimulate both Th1 and Th2 cytokine production in vivo [14]. CTLA-4 is also a CD80/...

Ngày tải lên: 12/08/2014, 13:22

... measured in supine subjects at the lat- eral epicondyle (typical FM tender point [8]), in fingertips II and III (that is, of the forefinger and middle finger) and in the lower arm (control point) using ... reactive hyperaemia in short-term and long-term type I diabetes – continuous monitoring by a combined laser Dop- pler and transcutaneous oxygen probe. VASA 1990, 19:8-15...

Ngày tải lên: 09/08/2014, 06:22

... native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. ... engineering approaches are being aggressively investigated in an effort to engineer cartilage in vitro to produce grafts that will facilitate regeneration of articular cart...

Ngày tải lên: 09/08/2014, 10:21

... fundamental to early eukaryotes, which are likely to be also shared by extant eukaryotes, they mi ght show similar evolutionary patterns in differ- ent eukaryotic kingdoms . Specifically, copy numbers ... estimated by using both NJ and ML methods. The same criteria as used in analysis I were followed to identify orthogroups and infer early eukaryo- tic gene duplication. As sum...

Ngày tải lên: 09/08/2014, 20:21

... first performed by Schede in 1866 and then by Sauerbruch in 1907. Meanwhile, partial sternectomy for a primary sarcoma w as first described by Holden in 1878. In 1959, Brodin and L inden first * ... that underwent sternectomy followed by systemic che- motherapy and irradiation. Follow-up examinations con- tinued for 30 and 36 months and they were alive and living a...

Ngày tải lên: 11/08/2014, 11:23