Báo cáo y học: " Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis" doc
Báo cáo y học: " Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis" doc
... Interferon-? inhibits interleukin-1?-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis Arthritis Research & Therapy ... expres-sion in joints affected by AIA on Day 1. Abundant stain-ing was detected in the synovial lining layer, joint exudate and focal areas of synovial infiltration; it was comparable in WT and IFN-γ-/- ... IL-1β induced MMP secretion by RA FLS In RA cartilage damage is predominantly mediated by theMMPs; most notably MMP-1, -13 and -3 [19]. Their syn-thesis is driven by pro-inflammatory cytokines,...
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Báo cáo y học: "Regulation of CD154-induced interleukin-12 production in synovial fluid macrophage" pps
... amplification in a 50-µl reaction mixture con-taining 1 U of DynaZyme II DNA polymerase (FinnzymesOY, Espoo, Finland), 5 µl of 10 × PCR Buffer (FinnzymesOY), 0.2 mM of each dNTP, and 15 pmol/µl ... levelsCytokine levels in culture supernatants and SF were mea-sured by cytokine-specific ELISAs. IL-12p40 and IL-12p70 were measured using matched capture and detection antibody pairs and standards ... thoseobtained studying IL-12p70 and p40 production by ELISA, showing that that low expression of p35 mRNAmay explain the lack of p70 protein production in SFmacrophages.Available online http://arthritis-research.com/4/5/R9Page...
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Báo cáo y học: "Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis" potx
... d by RASF finally cause thedestruction of the joint [3].As loss of integrity of compartment borders in thejoint b etween cartilage and SF is a key event in RA, wewere interested in analyzing ... in designing the study, in analysis and interpretation of the data and in drafting the manuscript. AKB conceived the study and was responsible forits design and coordination, analysis and interpretation ... chemo-attractant. Synovial cells in early passages (P3 and P4) and in late passages(P5 and P6; as indicated) were harvested with trypsinincubation for two minutes, resuspended in DMEMwithout...
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Báo cáo y học: " Simvastatin inhibits TGFb1-induced fibronectin in human airway fibroblasts" ppsx
... [4-6]. Airway fibroblasts and myofibroblasts are a primary source ofECM proteins, including fibronectin, in subepithelialfibrosis linked to airway remodeling [7]. Targeting and understanding molecular ... GGT1-cata-lyzed geranylgeranylation are crucial for TGFb1-inducedfib ronectin expression in airway fibroblasts. These find-ings are s upported by studies using human fetal lung fibroblasts demonstrating ... signaling in TGFb1-induced fibronectin expression by bronchial fibroblasts fromnon-asthmatic and asthmatic subjects.Methods: We used simvastatin (1-15 μM) to inhibit 3-hydroxy-3-methlyglutaryl-coenzyme...
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Báo cáo y học: "β Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells" ppt
... wild-type and trans-genic mice are shown in Fig. 2.Increased cell proliferation and Th1 cytokine production in lymph node cells from transgenic miceThe draining axillary and popliteal lymph ... wild-type mouse, and alarger joint (b), show a smooth cartilage surface without any cartilage or bone destruction. (c) The synovial lining layer is composed of flat synovial cells or is mildly hyperplastic. ... production of theTh1 cytokines TNFα and IFNγ in cultures of transgenicdraining lymph node cells after arthritis induction and afterlong-standing arthritis. These cytokines are involved in thepathogenesis...
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Báo cáo y học: " Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4" potx
... expressionincreased significantly in R and AR, and blockade ofCD28 decreased the Th2 cytokine production, indicatingthe involvement of CD28 in Th2 cell activation in allergy. It is noteworthy that ... initially shown to selectively induce highlevels of IL-10 and IL-4, but is also able to stimulateboth Th1 and Th2 cytokine production in vivo [14].CTLA-4 is also a CD80/CD86-binding protein. ... AM,Guillot C, Badier M, Bongrand P, Vervloet D, Magnan A: Assessment of Tlymphocyte cytokine production in induced sputum from asthmatics: aflow cytometry study. Clin Exp Allergy 2003, 33:1238-1243.22....
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Báo cáo y học: "Microcirculation abnormalities in patients with fibromyalgia – measured by capillary microscopy and laser fluxmetry" ppt
... measured in supine subjects at the lat-eral epicondyle (typical FM tender point [8]), in fingertips II and III (that is, of the forefinger and middle finger) and in thelower arm (control point) using ... reactive hyperaemia in short-term and long-term type Idiabetes – continuous monitoring by a combined laser Dop-pler and transcutaneous oxygen probe. VASA 1990, 19:8-15.14. Maricq HR, LeRoy EC, ... have already been observed in FM, SSc, and RA [7,17]. However, the changes in FMsupport the hypothesis of increased sympathetic activity, and hence a functional hyperexcitability of the sympatheticnervous...
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Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects" ppsx
... native and synthetic biomaterials. Clinically significant and satisfactory resultsfrom applying autologous chondrocytes seeded in fibrin within abiodegradable polymeric material were recently reported. ... engineering approaches are beingaggressively investigated in an effort to engineer cartilage in vitro to produce grafts that will facilitate regeneration of articular cartilage in vivo. In most ... BioSeed-C (a polyglycolic/polylacticacid and polydioxane based material), and culture-expandedautologous chondrocytes, suspended in fibrin, are seeded and dispersed within the matrix. BioSeed-C...
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Báo cáo y học: "Phylogenetic detection of numerous gene duplications shared by animals, fungi and plants" ppsx
... fundamental to early eukaryotes,which are likely to be also shared by extant eukaryotes,they mi ght show similar evolutionary patterns in differ-ent eukaryotic kingdoms . Specifically, copy numbers ... estimated by using both NJ and MLmethods. The same criteria as used in analysis I werefollowed to identify orthogroups and infer early eukaryo-tic gene duplication. As summarized in Table 4, ... dePamphilis CW,Ma H: Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins. PlantPhysiol 2004, 135:1084-1099.41. Xu G,...
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Báo cáo y học: " Solitary metastatic adenocarcinoma of the sternum treated by total sternectomy and chest wall reconstruction using a Gore-Tex patch and myocutaneous flap: a case report" docx
... first performed by Schede in 1866 and then by Sauerbruch in 1907. Meanwhile, partialsternectomy for a primary sarcoma w as first described by Holden in 1878. In 1959, Brodin and L inden first* ... thatunderwent sternectomy followed by systemic che-motherapy and irradiation. Follow-up examinations con-tinued for 30 and 36 months and they were alive and living a good quality of life during this period. ... oral cyclophosphamide at adose of 75 mg/m2on days 1 through 14, 60 mg/m2ofepirubicin on days 1 and 8, and 500 mg/m2of fluorour-acil intravenously on days 1 and 8. During her CEFtherapy...
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