... first glimpses into
the haplotypes that might exist within the genome and have
important implications for our ability to map disease genes
in the near future. Interestingly, these publications ... could then be scanned with existing technology,
without it being necessary to type every DNA variant indi-
vidually in an attempt to identify the functional polymor-
phism responsible for...
... signaling
pathway. It was apparent that the kinome interlinks the
proteome and that cellular behavior may be coordinated by
a global signaling architecture.
Yitzak Pilpel (Weizmann Institute ... contributors in the retention of the two
surviving duplicates and in their acquisition of distinct
functions. Increasing the number of phosphorylation sites
increases the probabilities o...
... PIR sites.
HDAC4 was reported to physically interact with the
53BP1 protein and thus may bring this protein to PIR
sites. It will be a matter of future experiments to distin-
guish between these ... mock, uninfected cells, Inf - cells infected with the HIV-1-based vector, Inf+II - cells infected
with the HIV-1-based vector and treated with the integrase inhibitor (added together with...
... N-butyl ace-
tate or toluene. Before letting the patient breath the air in
the chamber, we ensured that the initial concentration
burst was over. For the liquid aerosols that we tested, the
initial ... concentration to stabilize
in the chamber for five different sets of experiments:
three with N-butyl acetate and two with toluene. This
suggests that a waiting time (burn -in period)...
... primary OA is ageing. Functional articular cartilage is
maintained by the cartilage cells, chondrocytes. Changes
in chondrocytes, leading to the inability of these cells to
maintain the homeostasis ... interleukin; MMP-13 = matrix metalloproteinase 13; OA = osteoarthritis;
TGFβ = transforming growth factor beta; TNF = tumor necrosis factor.
Competing interests
The authors declare that...
... CD8
+
and CD4/CD8 T cells using flow cytometry.
†
CD4
+
T cells and CD8
+
T cells are shown as the percentage of total lymphocytes in BALF, i.e. cells gated in the lymphocyte population.
Neutrophils, ... The results indicate that pulmonary CCR2
+
T cells and MCP-1 contribute to the
pathogenesis of pediatric ILD and might provide a novel target for therapeutic...
... and
electrolyte abnormalities. Therefore, few centres appeared to
be interested in this novel treatment.
In contrast, our intensive care unit was using TH in selected
patients with severe traumatic brain ... physicians became
sceptical that the unproven benefit of TH was outweighed by
the possibility of adverse effects with this treatment.
In 1991, in a pivotal study conducted in...
... result. In human acute pancreatitis,
the situation is completely different: patients with pancreatitis
present at different moments after the start of symptoms, and
thus at different stages of the ... pancreatic
superinfection, but to a lesser extent than prophylactic
administration of antibiotics. Parallel to this observation, they
found that mortality is again significantly lower after...