Báo cáo y học: "Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis" potx

... patients with rheumatoid arthritis. Cytokine 2008, 42:170-178. doi:10.1186/ar2955 Cite this article as: Denk et al.: Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. ... receptor in synovial fibroblasts in RA correlates with aggressiveness of the fibroblasts. Slit3 reduces the migratory activity of synovial cells from pati...

Ngày tải lên: 12/08/2014, 12:20

... respectively, of predicting withdrawal of infliximab therapy due to inefficacy (Table 3). Taking into account the 13.6% a priori chance to withdraw therapy due to inefficacy, a DAS28 of at least ... standard infliximab dosage of 3 mg/kg every 8 weeks was reinstituted in a majority of patients beginning in June 2002, the time at which infliximab became a reimbursable medicine in...

Ngày tải lên: 09/08/2014, 08:22

... the intra-assay and inter-assay coefficient of variation is <5%. The assay is not influenced by rheuma- toid factors. The serum concentrations of COMP obtained by this assay are highly correlated ... remains a subject of controversy regarding technical details [11]. Also, radiography is impractical in early stages of drug development, i.e. for proof of drug efficacy in small...

Ngày tải lên: 09/08/2014, 01:21

... carti- lage degradation by synovial fibroblasts [24]. Increased expression of cathepsin K around lymphocytic infiltrates in synovial tissue seems to facilitate the movement of mono- nuclear cells ... cathepsin K protein was local- ised in synovial fibroblasts, stromal multinucleated giant cells and CD68 + macrophage-like synoviocytes. Highly Table 4 Correlations of catheps...

Ngày tải lên: 09/08/2014, 06:22

... proinflammatory and anti-inflammatory effects in animal models of inflammatory diseases. An analysis of cytokine and neuropeptide content of synovial fluid from patients with rheumatoid arthritis ... recently been realized that the peripheral nervous system has a key role in modulating the severity of RA [2–4]. Synovial tissue is richly innervated with neuropeptide-containin...

Ngày tải lên: 09/08/2014, 06:23

... (and reversibly) impair endothelial function [7]. Reduction of inflammation using anti-TNF therapy in RA is rapidly (although transiently) followed by improvement of the endothelial function [8]. Interestingly, ... measurement of endothelial function is highly dependent upon current levels of inflammation. In healthy people, the inflammatory response elicited by vaccination is suf...

Ngày tải lên: 09/08/2014, 10:22

... fragments of a mono- clonal antibody directed against a specific target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-chain antibody fragments ... extra-domain A (EDA) of fibronectin, with the anti-inflammatory cytokine IL-10. They showed the accumulation of this fusion protein at the site of inflammation, g...

Ngày tải lên: 09/08/2014, 14:22

... only one of the main inflammatory cytokine-producing cells in the RA synovial tis- sue, but they also differentiate into bone resorbing osteo- clasts, which are implicated in RA inflammatory bone ... strongly express the B7-2 molecule (CD86) in RA synovial tissue. Figure 4 Evaluation of cytokine production by ELISA assayEvaluation of cytokine production by ELISA assay. Evaluat...

Ngày tải lên: 12/08/2014, 11:22

... be affected by the inflammatory process in RA [20]. Consid- ering that this disease is char acteriz ed by pers istent high levels of proinflammatory cytokines [21] and accumulation of inflammatory cells ... The initial treatment plan was mouth-rinsing with chlorhexidine 0.12% four times a day and antibiotic therapy with Clin- damycin 300 mg twice a day for 10 days, since the patient had...

Ngày tải lên: 11/08/2014, 20:20

... F, Ficheux H, Pujol JP: Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondro- cytes cultured in hypoxia: a potential mechanism ... Canada) containing hydroxide peroxide. Slides were counterstained with hematoxylin/eosin. The staining specificity of the antibody used was determined using three controls according t...

Ngày tải lên: 09/08/2014, 10:23