Báo cáo y học: "Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints " potx

... also of interest to comment on the question of potential compensation between the two TSPs. There is no evidence to date for compensation. Although we have not tested whether upregulation of TSP1 ... ingrowth into the body of the disc did not occur. The results of the quantitative assessment of the vascular bed in soft tissue along the disc margins that we...

Ngày tải lên: 09/08/2014, 10:23

... its validity in other populations. Competing interests The authors declare that they have no competing interests. Authors' contributions GT analysed the data and drafted the manuscript. SS provided support ... and progress notes. A review of the VA electronic medical records of the study population was conducted to obtain information on individual components of the RA...

Ngày tải lên: 09/08/2014, 10:23

... Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints. Arthritis Research & Therapy ... and those treated with FTY720 (Figure 4d) in the long-term experiments. FTY720 treatment does not have an effect on the occupancy of lym...

Ngày tải lên: 12/08/2014, 12:20

... experiments using a photoaffinity labeling technique is that the photoactivata- ble ligand binds with high affinity to the receptor and that the receptor is not destroyed or deactivated by the light used ... significant differences between the relative agonist activities of the peptides: j , P > 0.001 vs. control without peptide. k The ratio of cAMP production of transfec...

Ngày tải lên: 31/03/2014, 08:20

... radicals. Treatment with the two GAGs pro- duced a significant attenuation of cartilage injury. The production of oxygen free radicals that occurs with the development of arthritis in the articular ... with HYA and C4S in a rat model of CIA. The choice of these two compounds from other GAGs was made on the basis of the evidence that they show the best antioxi...

Ngày tải lên: 09/08/2014, 01:21

... phase. Conclusions Our data indicate that the susceptibility of RASFs to FasL- and TRAIL-induced apoptosis depends on the cell cycle. These results may explain some conflicting data on the ability of ... hypothesised that the suscepti- bility of RASFs to receptor-mediated apoptosis depends on the proliferation status of these cells and, therefore, analysed the...

Ngày tải lên: 09/08/2014, 01:22

... and suggests that IL-10 augmentation is specific not only to cell type but also to the stimulus. Comparing these data with those found in the mouse, the augmentation of IL-10 and downregulation of TNF-α ... raised by increasing the activity of adenylate cyclase or by decreasing the activity of phosphodi- esterases. In the light of the observation that a physiologi-...

Ngày tải lên: 09/08/2014, 01:23

... investigated. Materials and methods Patients and controls The study was approved by the Ethics Committee of the Medical Faculty of the MLU Halle-Wittenberg. All patients attended the study after ... later years, the OR of 0.31 points to inversion into a significant protective effect. Our data contrast with those of other investigations reporting the lack of associa...

Ngày tải lên: 09/08/2014, 01:23

... identical to very early rheumatoid arthritis. Evaluation of the cytokine profile at the earliest time points after onset of symptoms could identify novel targets that prevent progression to chronic ... (Th2) factors contribute to the resolution. In this context, the study by Raza and colleagues raises questions about the role of T cells in RA and other forms of inflamma...

Ngày tải lên: 09/08/2014, 06:23

... year of treatment initiation, DAS28, and disease duration prior to treatment initi- ation did not predict the level of adherence to therapy. Discussion The results presented in this study demonstrate ... by the treating physician, and inter-observer variation in the classification of the stop reason therefore exists. The reason for the low percentages of termination be...

Ngày tải lên: 09/08/2014, 08:23