Báo cáo y học: "TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies" pot

... RESEARC H ARTIC LE Open Access TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies Jessica AB van Nies 1* , Rute B Marques 1 , ... TRAF1/C5 susceptibility risk genotype in RA patients [10]. Both polymorphisms analyzed in the present study, rs10818488 and rs2416808, are in complete linkage-dise...

Ngày tải lên: 12/08/2014, 11:23

... adiponectin and inflammatory arthritis. Additional mechanistic and longitudinal studies in humans in the future might help to correlate our findings with clinical features. Competing interests The ... Lee YA, Hong SJ, Lee SH, Yang HI, Yoo MC: Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in inter- leukin-1beta stimulated fibroblast-like synov...

Ngày tải lên: 09/08/2014, 14:22

... compared with, the waiting list group are clearly clinically relevant. The minimal acu- puncture intervention used was, according to the investi- gators, designed to minimise potential physiological effects ... individual (e.g. genotype, coping strategy, expectation and previous experiences). Given the com- plexity, it is not surprising that a variety of control inter- ventions have been...

Ngày tải lên: 13/08/2014, 15:21

... tight glycaemia control by intensive insulin therapy in every ICU?. Crit Care 2006, 10:130. 38. Preiser JC, Devos P: Clinical experience with tight glucose control by intensive insulin therapy. Crit ... with known diabetes [41-46]. In the recent SAPS III study, diabetes, with or without insulin treatment, was associated with a worse hospital mortality in multivariate analysi...

Ngày tải lên: 13/08/2014, 20:21

... abnormal profile in DHPLC were sequenced by the ABI Prism BigDye Termi- nator cycle sequencing ready reaction kit (Perkin Elmer- Applied Biosystems Inc., Foster City, CA). DHPLC analysis of the VAPB ... muta- tions in this gene are a rare cause of non familial forms of ALS [14,15]. The finding by Nishimura et al. [16] of a missense muta- tion in the VAMP/synaptobrevin -associated membr...

Ngày tải lên: 11/08/2014, 08:20

... total mor- tality and cancer mortality rates among men with estab- lished DD [6], suggesting the pathophysiology of this disease may overlap with that of certain cancers. β- catenin, the central ... phosphorylation at threonine 41, serine 37 and serine 33. This hyper-phosphorylated form of β-catenin is then recognized by the F-box containing protein slimb/β-TrCP, a component of the E3...

Ngày tải lên: 11/08/2014, 08:20

... respectively). Diabetes was not associated with mortality on univariate analysis and therefore was not entered into the multivariate model. Mortality is defined throughout as hospital, not ICU, mortality. ... Hypoglycemia, either spontaneous or occurring as a complication of IIT, is a frequent occurrence in critically ill patients and is independently associated w...

Ngày tải lên: 20/06/2014, 22:20

... of HIF-1α with MVD and the VEGF/KDR activated MVD in OA is consistent with the notion that VEGF is induced by hypoxia after activation of the HIF-α pathway. This is further reinforced by the direct ... (Print ISSN 1478-6354; Online ISSN 1478-6362). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, pr...

Ngày tải lên: 09/08/2014, 01:21

... many parallels with halted apoptosis. We recently found that vimentin is citrullinated in dying human macrophages [11]. Because macrophages are abundant in the RA synovium, it is not surprising ... immunohistochemical staining was observed in a few, widely dispersed cells but not in extracellular structures. The explanation for this discrepancy is probably that the antibod...

Ngày tải lên: 09/08/2014, 01:23

... 6 Localisation of citrullinated proteins in synovial membranesLocalisation of citrullinated proteins in synovial membranes. (a) Immunostaining of citrullinated proteins by the anti-modified citrulline ... proteins in the joint driving the immune response. Citrull- inated fibrin is a candidate because it is present in interstitial deposits in the synovial membrane [13] and is r...

Ngày tải lên: 09/08/2014, 07:20