Báo cáo y học: "Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvemen" doc

... tissue-type plasminogen activator; TNF: tumor necrosis factor; u-PA: urokinase-type plasminogen activator; u-PA -/- : urokinase-type plasminogen activator gene deficient; u-PAR: urokinase-type plasminogen ... 12:R37 http:/ /arthritis- research.com/content/12/2/R37 Page 12 of 13 RESEA R C H ARTIC L E Open Access Urokinase-type plasminogen activator and arthritis progressio...

Ngày tải lên: 12/08/2014, 11:23

... ecotropic Friend and Moloney MLV (Table 2) by assaying for a reduction in virus infectivity following incubation of virus-containing supernatant Figure 1 Sensitivity of PCR screening for XMRV in PBMC ... University Q125 + ++ ++ - ND + indicates neutralising activity; ++ indicates strong neutralising activity; - indicates no neutralising activity; ND is no determined. Groom et al. Retrov...

Ngày tải lên: 12/08/2014, 23:23

... enthalpy of the transition f or the E, SM4, SM1 and B1 fibritins increases linearly with an increasing number of amino-acid r esidues in the coiled-coil region. In contrast to the independent melting ... of melting between the C-terminal domain and the coiled-coil region (Fig. 3A). Significant stabilization of fibritin M, in comparison with a wild-type fibritin, can be explained mai...

Ngày tải lên: 24/03/2014, 03:21

... expression increased in the aging thymus. The CCR5 ligands, CCL4 and CCL5, increase in the thymic parenchyma as revealed by the age-associated increases in the staining of thymocytes and microenvironmental ... the thymus with age. Hy- pothesizing that the increased expression of chemokines and the CCR5 receptor may play a role in adipocyte recruitment and/ or differenti...

Ngày tải lên: 08/08/2014, 18:20

... immunos- timulatory mtDNA was involved in human arthritis by assay- ing the levels of extracellular mtDNA in plasma and synovial fluid (SF) samples from patients with rheumatoid arthritis (RA) and from ... bands were revealed by silver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft- ware (BioSystematica, Plymouth, U...

Ngày tải lên: 09/08/2014, 01:23

... alterations resem- bling those found in autoimmune diseases, especially in RA and in systemic lupus erythematosus (SLE) [19], exist in healthy aged individuals, including an increase in autoantibodies, ... of arthritis, but in ageing and in auto- immune diseases there is a complete disequilibrium between proinflammatory cytokines and anti-inflammatory cytokines [2,6,9...

Ngày tải lên: 09/08/2014, 01:23

... clinical trials are positive? The answer is this is ‘yes and no’. Certainly, skepticism and vigilance are required with industry- sponsored trials because there are inevitably large financial interests, ... of rheumatoid arthritis with methotrexate and hydroxychloro- quine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomiz...

Ngày tải lên: 09/08/2014, 01:23

... artery specimens with active inflammation [6]. Thus, the process of aneurysm formation in systemic inflammatory diseases is complex, multifactorial, and likely involves immune and proteolytic ... from hypertension, heritable disorders like Marfan syndrome, bicuspid valve disease, and inflamma- tory and infectious processes. Among the systemic inflamma- tory diseases, thora...

Ngày tải lên: 09/08/2014, 13:22

... primarily affects the synovial lining, resulting in destructive changes to the joints and soft tissues, most commonly in the hand and wrist. Approximately 50% of patients with RA have tendon involvement, ... Galardy RE, Grobelny D, Foellmer HG, Fernandez LA: Inhibition of angiogenesis by the matrix metalloprotease inhibitor N- [2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]- L-...

Ngày tải lên: 09/08/2014, 14:20

... efficiently degrade cytosolic DNA [54]. Ankylosing spondylitis, TLR2 and TLR4 Ankylosing spondylitis is a multifactorial and polygenic inflammatory rheumatic disease with a poorly understood pathophysiology. ... Joosten and colleagues have shown a proinflammatory role for NOD2 and an anti-inflammatory role for NOD1 in a streptococcal cell wall induced model of arthritis [3...

Ngày tải lên: 09/08/2014, 14:21