Báo cáo y học: "Vasculogenesis in rheumatoid arthritis" pptx

... origin as Lin − /7-aminoactinomycin D (7AAD) − / CD34 + /CD133 + /VEGFR-2 + cells and the number of these cells was indeed higher in RA patients compared with controls. In addition, the colony-forming ... late-outgrowth EPCs of solely heman gioblastic origin may be involved in vascular repair. As this EPC subset may be preferentially involved in the active stage of the disease, i...

Ngày tải lên: 12/08/2014, 11:23

... homology to other HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the ... to HA binding are also shown in Fig. 1A, inset a. Cys-266 in the transmembrane domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used for pa...

Ngày tải lên: 09/08/2014, 01:21

... cause proteins to become non-enzymatically damaged by glyoxidation. This process, which involves primarily lysine and arginine residues, ultimately results in the generation of advanced glycation ... hyaluronan and chondroitin sulfate [39,40] and damage the hyaluronan- binding region of the proteoglycan core protein, thereby interfering with proteoglycan–hyaluronan interactions [41]. In a...

Ngày tải lên: 09/08/2014, 01:24

... mg/week in the original Table 2 Treatment terminations for ineffectiveness in original and re-employed methotrexate therapies Re-employed course Total No inefficacy Inefficacy Original course No inefficacy ... g/day in original courses and 2.1 ± 0.5 g/day in re- employed courses (P = 0.30, by Wilcoxon test). Among patients with ineffective original sulfasalazine therapies (n = 16), do...

Ngày tải lên: 09/08/2014, 07:20

... to a synthetic blockade of the second step of the enzyme P450c17, again induced by inflammatory cytokines such as IL1β and TNF. Increased DHEAS levels during treatment with TNF antagonists in active ... the inflammatory reaction, which supports a pro-inflam- matory milieu in RA joints. Recently, male gender has been found to be a major predictor of remission in early RA. Introduction Th...

Ngày tải lên: 09/08/2014, 14:22

... antirheumatic drugs included in the study Abatacept Adalimumab Anakinra Azathioprine Cyclosporin D-penicillamine Etanercept Gold Hydroxychloroquine Infliximab Leflunomide Methotrexate Minocycline Rituximab Sulfasalazine Table ... 65 years or older, who are of low to moderate income, and who may suffer financial hardship in paying for their medica- tion. The PACE program provides pharmacy...

Ngày tải lên: 12/08/2014, 15:22

... fluorescein isothiocyanate- conjugated anti-mouse antisera for 30 minutes at 4°C. Stained cells were fixed and 1 × 10 4 viable cells were analysed by flow cytometry using standard settings. Induction ... G 2 / M phase, indicating that the cell population remained highly synchronised. Cell cycle analysis after 42 and 48 hours confirmed an increase of RASFs in G 0 /G 1 phase, indicating tha...

Ngày tải lên: 09/08/2014, 01:22

... Ceuppens JL, Luyten FP: Bone morpho- genetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. ... of synovial tissue shows chronic changes shortly after the onset of symptoms, and the cytokine profile in early disease as determined by immunohistochemistry is nearly identical to...

Ngày tải lên: 09/08/2014, 06:23

... Rhuematology (ACR) criteria [13]. Drug-induced remission may be defined as minimal or no clinically detectable disease activity in the presence of continuing drug treatment, which is not stopped or inter- rupted, ... criteria which may be used in the definition of remission, includ- ing single clinical variables, response criteria, pooled indices such as the DAS and ACR and then imaging t...

Ngày tải lên: 12/08/2014, 14:21

... [23]. This link between proinflammatory cytokines and osteoclast formation most likely explains why cytokine-targeted therapy, particularly blockade of TNF, is highly effective in retarding structural damage ... lineage types such as Kupffer cells in the liver or microglia in the brain. It is not fully clear whether some monocytes entering an inflamed joint are already committed to the...

Ngày tải lên: 09/08/2014, 01:22