Báo cáo y học: "Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity" doc

... (0.2-2.02) a 0.3946 a Circulating endothelial cell (CEC) number has been evaluated in 15 healthy controls. 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin - , ... endothelial progenitor cell (EPC) levels in rheumatoid arthritis (RA) with disease activity. Correlation between EPC counts and disea...

Ngày tải lên: 12/08/2014, 11:23

... correlated with serum levels obtained by the original inhibition assay (r values >0.9 in RA samples) (T Saxne and D Heinegård, unpublished). Samples obtained at baseline and after 3 and 6 months ... protection reported in clinical trials are corroborated by changing levels of circulating COMP. Rheumatoid arthritis patients commencing treatment with infliximab (N= 32...

Ngày tải lên: 09/08/2014, 01:21

... E-cadherin in syn- ovial tissue [29], our study is in line with a study by Trollmo and colleagues [30], describing E-cadherin expression in the lining layer of healthy synovial tissue, indicating ... 6). Administra- tion of BMP-7 to healthy FLSs in vitro had no effect on α-sma Figure 1 Haematoxylin and eosin staining on healthy and arthritic synovial tissueHaematoxylin and e...

Ngày tải lên: 09/08/2014, 08:23

... by a variety of extracellular stimuli [1]. FAK and Pyk2 associate with the cytoskeleton and with integrin-signaling complexes by binding to Src kinase and paxillin [2-5]. FAK is rapidly tyrosine ... [18]. pPyk2 immunostaining on ST lining and MΦs was significantly higher in RA (lining cells = 60% and MΦs = 46%) compared to OA (lining cells = 30% and MΦs = 23%) and ND (lini...

Ngày tải lên: 09/08/2014, 10:21

... article Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity Bert Vander Cruyssen 1 , ... lack of efficacy. In conclusion, long-term maintenance therapy with infliximab 3 mg/ kg is effective in producing further reductions in disease activity. Disease a...

Ngày tải lên: 09/08/2014, 08:22

... protein mutations in Drosophila. J Cell Biol 1996, 133:1293-1305. 49. Hug C, Jay PY, Reddy I, McNally JG, Bridgman PC, Elson EL, Cooper JA: Capping protein levels influence actin assembly and cell ... Trabandt A, Key- sser M, Gay RE, Gay S: Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoi...

Ngày tải lên: 09/08/2014, 08:23

... target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-chain antibody fragments for targeting and in vivo imaging of tumors is ... neutralizing anti-TNF-antibodies in the treatment of rheumatoid arthritis has paved the way for using immunocytokines in non-lethal diseases. The study of Kathrin Schwager and...

Ngày tải lên: 09/08/2014, 14:22

... that alternative therapy would result in a greater increase in protein C level from study Day 1 to study Day 7 com- pared with standard therapy with DAA. Secondary objectives included: safety profile of ... 28-day mortality by Day 4 protein C level. Twenty-eight-day mortality is shown based on Day 4 protein C levels by categories: normal (> 80%); moderately deficient (41 to 80%);...

Ngày tải lên: 14/08/2014, 07:21

... study showed that, in RA tis- sues, sPLA 2 -IIA is distributed in various cells, such as synovial lining and sublining cells and vascular cells, as well as in extracellular matrix fibers [46]. In ... is induced rather specifically in VSMC in synovial tissues with active RA. In inactive RA sections, sPLA 2 -IIF showed sporadic and weak staining in individual cells (Fig. 4...

Ngày tải lên: 19/02/2014, 16:20

... activity in some inflammatory diseases and catalyzes hydrolysis of aminophos- pholipids, including PS, as well as phosphatidylcholine and phsophatidylethanolamine, all contained in microvesicles ... prothrombinase capture assay and flow cytometry in 43 patients with pSS, 20 with SLE and 24 with RA and in 44 healthy controls (HCs). Secretory phospholipase A2 (sPLA2) act...

Ngày tải lên: 09/08/2014, 14:22