Báo cáo y học: "High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals" pdf

... R, Giri JG, Dayer JM: The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble ... that is stored in vesicles in resting conditions. This mechanism is inhibited by HDL, which may limit the inflammatory process by diminishing CCL2 production and, in turn, monocyte...

Ngày tải lên: 12/08/2014, 11:23

... 2 )in Streptomyces clavuligerus [1–7]. The subsequent hydroxyla- tion of DAOC to give deacetylcephalosporin C (DAC 3)is catalysed by a closely related oxygenase, deacetylcephalo- sporin C synthase ... contains eight arginine residues within, or close to, its active site that may be involved in catalysis. Arg258 has already been shown by structural and mutagenesis studies to bind the 5-...

Ngày tải lên: 18/03/2014, 01:20

... unit may be essential for the specific function of the mature protein product. This is usually achieved by cotrans- fecting cells with several independent constructs or by introducing a single ... lars.norderhaug@antibodydesign.com Abbreviations: IRES, internal ribosome entry site; SIgA, secretory IgA; pIgA, polymeric IgA; J-chain, joining chain; SC, secretory component; FITC, fluorescein i...

Ngày tải lên: 18/03/2014, 01:20

... was evidence of excessive activity (including a premature eyeblink) during the baseline period. They were also rejected if there was no evidence of an eyeblink having been evoked by the startle probe. Altogether, ... foreground unpleasant stimul i in comp arison with foreground plea- sant stimuli. The present study was designed to further investigate the laterality effect in human emo...

Ngày tải lên: 09/08/2014, 01:21

... mutations was higher in the FLS than in matched synovium. This is most probably because the cells bearing mutations in the intact tissue (synoviocytes in the intimal lining) represent only about 20% of ... granu- locyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest 1990, 86:1790-1798. 22. Rosengren S, Firestein GS, Boyle DL:...

Ngày tải lên: 09/08/2014, 06:22

... expression of a 92-kD gelatinase (type V collagenase) by rheumatoid syno- vial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest 1991, 88:1656-1662. 34. ... to Figure 1 Induction of multiple matrix metalloproteinase (MMP) protein by Staphylococcus aureus in human dermal fibroblastsInduction of multiple matrix metalloproteinase (MM...

Ngày tải lên: 09/08/2014, 08:23

... induction therapy; M, maintenance. Interventions are: ATG, anti-thymocyte globulin; Aza, azathioprine; CY, cyclophosphamide; DSG, deoxyspergualin; Eta, etanercept; GC, glucocorticoide; Inflix, infliximab; ... vitamin B supplemen- tation to be the standard of care, with rifampin being a good alternative in case of incompatibility. In some PSV, especially in WG, infliximab is used as salv...

Ngày tải lên: 09/08/2014, 14:22

... Brosch G: Binding mode analysis of 3-(4-benzoyl-1- methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, ... 3-(4- toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propena- mide; ( MS-275): [N-(2-aminophenyl)-4-[N-(pyridine-3- ylmethoxy-carbonyl)aminomethyl]benzamide]; (PDTC): ammo nium pyrrolidinedithioca...

Ngày tải lên: 11/08/2014, 08:22

... pro-inflammatory cytokines, although TNF-a production by endothelial cells is nor- mally only induced by inflammatory stimuli such as LPS or interleukin 1b [33,34]. In the future it would be inter- esting ... WA: Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells. Am J Physiol 1996, 270:C522-529. 23. Karin M, Greten FR: NF...

Ngày tải lên: 11/08/2014, 08:22

... and any accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this journal. Competing interests The authors declare that they have no competing interests. Authors' ... complaints of pleu- ritic chest pain, fever and weight loss. Radiological (chest X-ray, and chest computed tomography (CT)) and labora- tory (blood culture, urinary antige...

Ngày tải lên: 11/08/2014, 17:21