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Báo cáo y học: " The role of leptin in the respiratory system: an overview" pdf

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Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... up-regulation of many genes in E. coli including ahpC, mdaB, nfnB, nfo, sodA, yggX and ygfZ.Byanalyzing minimal inhibition concentration and inhibition zones of plumbagin in various gene-disruption mutants,ygfZ ... plumbaginwere then determined. The MIC of the parental strainwas expectedly much higher than those of the ΔygfZand ΔsodA mutants (Table 3). To ensure that the plum-bagin-sensitivity of the ΔygfZ ... activities of different YgfZ constructs to support the growth of the ΔygfZ E. coli strain in the presence of plumbagin. Plasmids were separately transformed into the ΔygfZ strain and assayed for the diameters...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"

... Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR. A pilot study of the tolerability and efficacy of antiviral therapy in hepatitis C virus-infected patients awaiting liver transplantation. ... transplant are more ill. The resulting poor synthetic function, presence of hepatic encephalopathy and hypersplenism limit the candidacy of patients for interferon-based therapies. Pre-transplant ... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

... glutamine and thereby give additional information intoits potential role in ligand binding. We also made the threeanalogous mutants of mouse PXR: I282Q, Q404H andQ404A. The wild-type and mutant ... of the human and mouse PXR ligand binding domains.By modeling the human PXR ligand binding domain wehave identified and mutated two polar residues in the puta-tive ligand binding pocket which ... likely to play a role in the molecular mechanisms behind common drug inter-actions. PXR is coexpressed in tissues where CYP3A isinduced and expressed [5]. The key role of PXRs in CYP3Ainduction...
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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

... werefound, in the second study, to be activated by the MRN complex only in the presence of DNA strandends, resulting in the phosphorylation of downstreamtargets [42]. Furthermore, both Nbs1 and the ... contains a forkhead-associated (FHA) domainand a Brca1 COOH-terminus (BRCT) domain in itsNH2-terminal region, as well as an Mre11-bindingdomain and an ATM-binding domain in its COOH-terminal ... formation of MRNfoci [19–21]. The Mre11-binding domain of human Nbs1 hasbeen localized to amino acids 682–693 in the COOH-terminal region of the protein. Deletion of this region of Nbs1 results in...
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Báo cáo y học: "Current role of surgery in small cell lung carcinoma" pot

... less than ayear, a small but significant difference in the survival wasshown in the two groups of the study: 4 year survival of 3% in the surgery arm and 7% in the radiotherapy arm. A5 year ... radiotherapy, has beentypically accepted as the cornerstone of therapy in SCLC[1]. Initially surgery was the treatment of choice for alltypes of lung cancer but it was abandoned for the subset of ... exclude the presence of nodal involvement. In stage I surgerymust always be followed by adjuvant chemotherapy, while in stage II and III surgery must be plannedonly in the context of clinical...
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Báo cáo y học: " Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease" docx

... that the oxidant/anti-oxidant imbalance isresolved with smoking cessation it further supports the role of antioxidant disturbances in the progression of COPD. The data however can not indicate the ... burden both directly as aresult of smoking and indirectly by the release of ROSwhich may not be adequately counterbalanced by the pulmonary antioxidant systems, resulting in net oxida-tive ... marker of oxidative stress in patients with chronic renal failureand individuals on hemodialysis therapy (12). In light of these findings the quantification of carbonyl residuesmay provide further...
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Báo cáo y học: "Contemporary epidemiology of gout in the UK general population" pot

... role of low-dose aspirin use, if any, may beminor on the risk of incident gout. Our study confirmed an increased risk of gout among users of cyclosporine (an immunosuppressant drug indicated in ... densitysampling. This was done by generating at random adate encompassed within the study period for each of the members of the study population. If the randomdate for a study member was included in ... including psoriasis, heart failure,hypertriglyceridemia, and cyclosporine therapy. Use of gout-specific treatment has remained relatively constant in recent years except for an increase of colchicine.IntroductionGout...
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Báo cáo y học: "Patients'''' recollections of experiences in the intensive care unit may affect their quality of life" doc

... of their condition until late in their ICU stay and some of them only after their discharge to the ward. However, during their ICU stay they continue to have an emotional life, in a mixture of ... forstress in our patients. This can be explained by the traditionallystrong family ties in the Portuguese culture. Pain came in fourth place in the ranking of stressors. This finding, togetherwith the ... procedures, maintenance of the day/night cycle, minimisa-tion of sensory stimuli and minimisation of noise and lights.Although for some patients the noise of alarms and seeingstaff around them may be...
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Báo cáo y học: " Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?" potx

... that the interaction isindependent from RNA and that the complex cofraction-ates with the miRNA miR-17. By using a two-hybrid assay,they map the interaction to the C-terminal domain in TRBP, ... Surprisingly, many RNAi suppressors are also inhibitors of the interferon (IFN)-induced protein kinase R (PKR) but the potential overlap between the RNAi and the IFN pathways remains to be determined. ... RNA binding protein that increases HIVexpression and replication by inhibiting PKR and by increasing translation of structured RNAs. Arecent report published in the Journal of Virology shows...
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