Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc

... 7500.Localization of GAD67 Expression in Human Airway EpitheliumTo determine the airway epithelial localization of GAD67 expression, bronchial biopsies were obtained byflexible bronchoscopy from the large airway ... 11:150http://respiratory-research.com/content/11/1/150Page 14 of 15 The data demonstrate there is expression of genes for acomplete GABAergic system in the airway epithelium.Interestingly, the expression of GAD67 was markedlymodified by smoking, ... GABAergic system wasexpressed in the airway epithelium (Figure 2C). Up-regulation of GAD67 in Large and Small Airway Epithelium of Healthy Smokers Of all of the GABAergic system genes expressed in the large...

Báo cáo y học: "Mouse maps of gene expression in the brain" pot

... normally express the gene of interest. The advantage of using the BAC as a cloning vector is that it cancarry as much as 200 kb of genomic DNA - typically enoughto include most, if not all, of the ... Centers [8,9]. In addition, for some of the most interesting expression patterns, the project isdeveloping lines where the BAC containing the genepromoter elements drive expression of the bacteriophage,Cre ... Europeaneffort led by Gregor Eichele at the Max-Planck-Institute of Biophysical Chemistry in Göttingen, Germany. In approach,this is a hybrid of the Allen Brain Atlas and GENSAT. The GenePaint atlas [10]...

Báo cáo y học: "Microarray analysis of microRNA expression in the developing mammalian brain" ppt

... closely related family members isan artifact of hybridization.Profile of microRNA expression in the developing mouse brainFigure 3Profile of microRNA expression in the developing mouse brain. ... technologyfor profiling the expression of microRNAs and other smallRNAs and apply this technology to the developing mamma-lian brain. Recently, Krichevsky et al. described the temporal expression of ... Quantification of microarray data using three synthetic RNAs: syn1, syn2 and syn3. Each data point is the average of two independent labelling/hybridization reactions. Probes for the three synthetic...

Báo cáo y học: "Microarray analysis of gene expression in lupus" ppt

... clus-tering of these genes was then performed to identify gene expression patterns among the study samples. As in the JDM study, a striking increase in the expression of a group of genes previously ... microarraysystem (Mergen ExpressChip DNA Microarray System Human HO4) in a study of 10 SLE patients and 8 healthycontrols. The Han study also detected an increased expression of several of the genes ... to be induced by IFN wasobserved in about half of the SLE subjects. The authorsidentified 23 of the 161 differentially expressed genes astargets of IFN by determining gene expression of PBMCcultured...

Báo cáo y học: "Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (International Cartilage Repair Society grade)" pptx

... translationparameter. In this system, we use the Gabor function as the mother wavelet. The equation is given by:where ωp is the center of frequency and λ is the frequencybandwidth. In the present study, ... differences in signal intensity suggestthat a superficial collagen network may be maintained in cartilage of the lateral condyle but may deteriorate in cartilage of the medial condyle and the medial tibial ... that they have no competing interests.Authors' contributionsHK, YN, MK, KY, YO, TS and KN participated in the ultrasoundmeasurement during the surgery. HK and KM participated in the analysis...

Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc

... aPiT1-binding immunoadhesin generated by f using the aminoterminal residues of the GALV (SEATO strain)Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... W hether, a lack of staining may comefrom an absence of receptor/transporter or an alteredaccessibility remains to be determined. In any case,lack of staining reflects major c hanges in the ... SUcomponent of retroviral envelope glycop roteins (Env) toextracellular domains of the cognate transporters usedas receptors [14,15]. Binding is ensured by the amino-terminal receptor bind ing domain...

Báo cáo y học: "Unusual presentation of cactus spines in the flank of an elderly man: a case report" pdf

... aware of the initial injury and at times, deeply penetrating splin-ters cannot be visualized. In these cases, unfortunately, the only indication of retained foreign material might beswelling, ... injuries typically have an injury track that leads to the splinter, facilitating detection and removal. Olderinjuries, however, may present in the context of infection,inflammation, induration, ... sensation of a foreignbody within a wound, they may not be aware of anyretained foreign matter [12]. Thus, any wound or lesionthat penetrates the skin should be evaluated for the pres-ence of foreign...

Báo cáo y học: "High prevalence of porcine Hokovirus in German wild boar populations" docx

... applied in this study to determine the copy numbers of PHoVgenomes. The assay was established to detect the newlydescribed parvovirus PHoV and the human PARV4/PARV5 using primers binding within ... Schönbuch which were nearlyidentical to the later sampling places in the hunting sea-son 2007/2008. In general, sampling, age determination of animals, storing and handling of samples were carriedout ... polymerase kit as described previouslyfor HEV [6]. Sequence of amplicons was determinedeither directly using the PCR product or after cloninginto vector pCR II TOPO (Invitrogen) by sequencingboth...

Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx

... have documented evidence for increased endogenous NO synthesis, suggest ing that overproduction of NO may be important in the pathogenesis of RA.  e in amed joint in RA is the predominant ... lysosomal lysosomal degradationdegradationȗȗP725NOATP ATP NOCytokines (INFCytokines (INF ȖȖ, IL, IL 2) synthesis2) synthesisNOT cellNONagy et al. Arthritis Research & Therapy ... for the TCR ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ ﬂ uxing.  e potential role of NO in the regulation of FcR gamma expression clearly needs...

Báo cáo y học: " Differential regulation of neurotrophin expression in human bronchial smooth muscle cells" pptx

... to increase the number of neurones and the neuropeptide content in the airways [15,16], and bothNGF and BDNF may evoke airway hyperreactivity in the airways [12-14]. In this respect, it is interesting ... there is evidence for a broad reg-ulatory role for neurotrophins in the airways. In additionto cells of the immune system, neurones may also be tar-gets for the neurotrophins in the airways. ... additionalintermediary mediators in BDNF induction. Our findingthat secretion of BDNF, but not NGF, was inhibited by the unselective COX inhibitor indomethacin and the COX-2inhibitor NS-398 imply the...

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