Báo cáo y học: "Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression" doc

... number of, yet not all, signaling pathways are altered in OA Ob in response to leptin. Conversely, partners of leptin signaling may be abnormal in OA Ob and this may stem from the possible abnormal ... response to leptin in OA Ob is likely and resembles what we previously observed for the response to IGF-1. First, an increase in phospho-PTP1B/Syp may be crucial...

Ngày tải lên: 12/08/2014, 11:22

... subjectsDiagnostic ability for separating healthy individuals from osteoarthritis subjects. The diagnostic ability for separating healthy individuals from osteoarthritis (OA) subjects (defined by Kellgren ... modalities – for instance, markers of dynamic turnover (typically biochemical markers) and assessment of current status (for example, by MRI) – may provide complementary in...

Ngày tải lên: 09/08/2014, 14:22

... the patent currently has a monopoly in the market. A heat stable formulation is cur- rently accessible in the US and may become more widely available later in 2010, but in many places ritonavir ... majority being trans- mission between non-regular partners [88], including female sex workers (FSW) and their clients. In one study, 60% of FSWs in China did not use condoms consist...

Ngày tải lên: 10/08/2014, 05:21

... (thin black line), 4 h/day restricted feeding (heavy line = day1, heavy green line = day 21), and total food depri- vation (heavy red line = day1). Temperature rises dramati- cally within 10 min ... of food anticipatory rhythms in behavior or physiology. There certainly are many other brain regions in which clock gene rhythms are reset by restricted feeding and persist during food depriv...

Ngày tải lên: 10/08/2014, 09:20

... ctively highlighted by test- ing in two different biological matrices accounting for different time windows of exposure [10]. In Spain, heroin and cocaine are usually consumed together by smoking, ... 3,4- Methylenedioxymethamphetamine (MDMA) intoxication in an infant chronically exposed to cocaine. Ther Drug Monit 2005, 27:409-411. 9. Smith FP, Kidwell DA: Cocaine in hair, saliva,...

Ngày tải lên: 10/08/2014, 23:21

... a single question where the clinician is asked to rate severity of illness on a 7 point scale (i.e., a score of 1 indicates not being ill and a score of 7 indicates being extremely ill) by comparing ... Global Impression, BCS: Barkley ADHD Current Symptoms Scale, BAI: Beck Anxiety Inventory, BDI: Beck Depression Inventory, IE: Independent Evaluator. Acknowledgements Support for the study wa...

Ngày tải lên: 11/08/2014, 15:22

... DeWoody K, Williamson P, Braun J, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Efficacy and safety of infliximab in patients with ankylosing spondylitis: ... Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A: A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Ac...

Ngày tải lên: 12/08/2014, 12:20

... lung injury/acute respiratory distress syndrome [10]. Many physicians have been and remain wary of ‘cookbook medicine’, however. Critics of clinical protocols worry that these decisional aids may ... reduce the quality of care by supplanting clinical judgment, breeding complacency, or stifling learning. These concerns cannot be ignored. In a highly technological era, when physician beds...

Ngày tải lên: 12/08/2014, 18:21

... the highest, baseline scores rated by patients were lowest, and baseline scores rated by physicians were in between. These findings may be due to Child and Adolescent Psychiatry and Mental Health ... patient or physician ratings at baseline. This may be due to parents being par- ticularly concerned about the emotional well-being of their children. Over time, however, there is a re...

Ngày tải lên: 13/08/2014, 18:21

... primary studies to obtain missing information. Two reviewers independently evaluated the quality of included trials using a detailed list of quality items assessing components of internal validity ... there may be a deficiency in self-management, or education. This may be partially tar- geted with the rehabilitation intervention, and patient education, as an additional part of multi...

Ngày tải lên: 12/08/2014, 18:21