Báo cáo y học: " ‘Rac’-ing upstream to treat rheumatoid arthritis" ppt

... Medrano-Ramirez G, Morales-Torres JL, Murphy FT, Musser TK, Straniero N, Vicente-Gonzales AV, Grossbard E: Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, ... Research & Therapy 2010, 12:109 http://arthritis-research.com/content/12/1/109 doi:10.1186/ar2924 Cite this article as: Firestein GS: ‘Rac’-ing upstream to treat rheumatoid...

Ngày tải lên: 12/08/2014, 11:22

... [6]. Also, rheumatoid nodules are very rare in the early phases of RA, and rheumatoid factor is present in only 50% of the patients with early RA [7]. Conversely, the serological factor that has ... Additionally, the functional conse- quence of carrying the C5-TRAF1 polymorphism is as yet unknown. Cytotoxic T lymphocyte antigen 4 A genetic risk factor that has been investigated frequently...

Ngày tải lên: 09/08/2014, 10:23

... inability to blind patients or investigators to treatment, lack of an intent -to- treat analysis, and inclusion of relatively small sample sizes. Treatment designs have progressed from initially looking ... results to real-world use. The advent of ‘treatment to target’ studies, while not designed for regulatory approval, provides an opportunity to study therapeutic regimens with t...

Ngày tải lên: 09/08/2014, 01:22

... 6 Krishnan et al. R510 Disability as a dichotomous entity Yet another way to use our data would be to define disabil- ity as an (artificially) dichotomous entity, for example HAQ- DI ≥ 1. Here ... widely used and validated tool to quan- tify self-reported functional disability in rheumatoid arthritis [10]. The questionnaire is usually self-administered but may also be completed face -...

Ngày tải lên: 09/08/2014, 01:24

... in untreated patients with rheumatoid arthritis. J Rheumatol 1999, 26:1701-1704. 7. Lakatos J, Harsagyi A: Serum total, HDL, LDL cholesterol, and triglyceride levels in patients with rheumatoid ... inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipopro- teinemia and reduced lipoprotein-associated platelet-activat- ing factor acetylhydrolase activity. A...

Ngày tải lên: 09/08/2014, 01:24

... cells are attracted to synovial tissue and the reason(s) why they get activated locally in the K/BXN serum transfer model to induce TGF-β1 have yet to be elucidated. Taken together, the data illustrate ... glycolipid pre- vents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001, 413(6855):531-534. 12. Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamur...

Ngày tải lên: 09/08/2014, 06:22

... regarding why most of the observed changes during the symptomatic phase of an inflam- matory disease, particularly in the symptomatic phase, are not specific for a certain inflammatory process ... radiolabeled substrates and analysis by thin-layer chromatography and HPLC. Aromatase expression was studied by immunohistochemistry. Dehydroepiandrosterone (DHEA) was converted into androstenediol,...

Ngày tải lên: 09/08/2014, 06:23

... size (paw size), total white cell count (WBC), total lymphocyte count (LY), percentage lymphocyte of total WBCs (LY%), total monocyte count (MO), percentage monocyte count (MO%), total neutrophil ... size (paw size), total white cell count (WBC), total lymphocyte count (LY), percentage lymphocyte of total WBCs (LY%), total monocyte count (MO), percentage monocyte count (MO%), total neutrop...

Ngày tải lên: 09/08/2014, 07:20

... genotypes (the two HLA-DRB1 genes expressed by any individual) determine the risk to develop RA. ‘Double dose’ genotypes such as DRB1*0401/DRB1*0404 carry very high risks to develop RA (it is very ... However, it is very different from the only other study of similar size, a metaanalysis of 14 published studies of HLA-DRB1 Commentary HLA-DRB1 genes and extraarticular rheumatoid arthriti...

Ngày tải lên: 09/08/2014, 07:20

... 3 Gelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and monocytes/macrophagesGelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) ... from synovial fluid of rheumatoid arthritis patients or from peripheral blood of healthy humans) were measured by flow cytometry using fluorescein isothiocyanate-labeled anti-CD147 mAb. A...

Ngày tải lên: 09/08/2014, 07:20