Báo cáo y học: "A peptidyl-glucosamine derivative affects IKKa kinase activity in human chondrocytes" doc

... cellular signaling. Chem Biol Interact 2009, 179:202-211. 38. Yin MJ, Yamamoto Y, Gaynor RB: The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase- beta. Nature ... peptidyl derivative can interfere with NF-B signaling pathway by inhibiting IKKa activity in human chondrocytes. However, the mechanism of action of the two mole cules is not c...

Ngày tải lên: 12/08/2014, 11:22

... adequately with everyday needs. This inadequacy may lead to heightened anxiety and depression, which in turn may worsen the everyday inad- equacy. It has been reported that this is (probably) a factor that ... chronic psychogenic and somatic pain, frequent hospital admissions, hospital dependency and dependency on oxygen. This metaphori- cally and literally suffocating disease status may ex...

Ngày tải lên: 08/08/2014, 23:20

... model of inflammatory arthritis [3]. The plasma kallikrein–kinin system (KKS), which is initiated by factor XIIa [5] or prolylcarboxypeptidase [6] after binding of high-molecular-mass kininogen ... inhibited inflammatory changes in joints, systemic inflammation, and activation of the kallikrein–kinin system [20]. Here we have demonstrated its efficiency in treat- ing HLA-B27-associated in...

Ngày tải lên: 09/08/2014, 06:22

... their kinase activity. The cdk inhibitors are grouped into two categories based on homology and pref- erential cdk-cyclin binding (Inks, comprising p15, p16, p18 and p19; and Cip/Kip, comprising ... Bennett B, Karin M, Yang L, Manning AM, Firestein GS: c-Jun N-terminal kinase is required for met- alloproteinase expression and joint destruction in inflamma- tory arthritis. J Clin Invest...

Ngày tải lên: 09/08/2014, 08:22

... Turpaz Y: Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays. ... allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet 2007, 81:114-126. 28. Yau C, Holmes CC...

Ngày tải lên: 09/08/2014, 22:23

... in staffing, work flow, decision making, com- munication, and reward systems. In exploring the meaning of organizational readiness and offering a theory of its determinants and outcomes, my intent ... discovery of new strategies or alter- native pathways, or they can show the equifinality of already known strategies. For example, in the theory that I describe, the keys to increasing rea...

Ngày tải lên: 11/08/2014, 05:21

... intravenously and erythromycin 1 g four times a day intravenously) was started to prevent possible intrauterine infection and nadroparin calcium (2850 IU once daily subcutaneously) was added ... can vary in presentation or can be entirely absent. Respiratory distress is found to predominate in 51% of patients, hypotension in 27% and coagulopathy in 12% (see [12]). The pathophysiology...

Ngày tải lên: 11/08/2014, 23:21

... cell-type-specific function and affects the retroviral life-cycle differently depending on cell type. Another possibility is that HDAC4 affects intracellular or intranuclear trafficking, which may ... Nijmegen breakage syndrome protein, an early sensor of double- strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase...

Ngày tải lên: 12/08/2014, 01:21

... 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By using a very ... be modified by maturation induced by either LPS or Der p 1. This lack of effect is at variance with previous findings in human lymphocytes, where FAAH is downregulated by LPS, interleukin-...

Ngày tải lên: 22/02/2014, 07:20

... dealing with this phenomenon by either applying the algorithm by hand (Eckert & Strube, 2000) or excluding these cases (Byron, 2002) from the evaluation. Because we included these cases in ... anaphor in terms of e.g. distance (in words, markables and sentences), compatibility in terms of agreement and identity of syntactic function. For these features, each instance contains only...

Ngày tải lên: 23/03/2014, 19:20