Báo cáo y học: "The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis" pps

... as: Pruijn GJM, et al.: The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis. Arthritis Research & Therapy 2010, 12:2??. Page 8 of 8 10. Jorgensen KT, ... cantly in uenced by TNFα blocking agents. © 2010 BioMed Central Ltd The use of citrullinated peptides and proteins for the diagnosis of rheumatoid...

Ngày tải lên: 12/08/2014, 11:22

... other cytokines (e.g. IL-8, IL-6, and leukotriene inhibitory factor), proteases, and prostaglandin E 2 (PGE 2 ) [30]. Synthesis of the inflammatory cytokines IL-1 and TNF-α and expression of their ... degradation exceeds synthesis. The balance between synthesis and degradation is affected by age and is regulated by several factors produced by the synovium and chondrocy...

Ngày tải lên: 09/08/2014, 01:21

... disease activity to study the validity of the Disease Activity Score and the DAS28. In a study performed in Italy in the late 1990s, it was found that the Disease Activity Score was the best measure to ... may be used to rank measures in a study, but it is difficult to generalise the values for sensitivity, specificity, and so on, beyond the study. This difficulty occu...

Ngày tải lên: 09/08/2014, 07:20

... not shown). The inflammatory environment of the synovial cavity is complex in RA, because most of cytokines are present in the synovial cavity and can interact with each other. We therefore investigated ... are cytokines characterized by com- plex reciprocal effects. They synergize to increase colla- gen synthesis by dermal fibroblasts or glycosaminoglycans synthesis by lung fibro...

Ngày tải lên: 12/08/2014, 14:22

... blockade of TNF and LTα) the number and the density of B cells in the synovial membrane and the frequency of ectopic germinal centres sig- nificantly decreased [5]. Conclusions In summary, the present ... currently unknown whether this approach to treatment is successful because of the pro- duction of early plasma cells due to the loss of rheumatoid fac- tor...

Ngày tải lên: 09/08/2014, 14:21

... http://arthritis-research.com/content/11/4/R103 Page 3 of 9 (page number not for citation purposes) informed consent and the study was evaluated and approved by the regional ethics committee. Laboratory analyses Erythrocyte sedimentation ... organised the data collection. PIG organised the immu- noassays. CO organised the analyses of ESR and CRP. All the authors contri...

Ngày tải lên: 09/08/2014, 14:22

... Due to the presence of highly acti- vated NF-κB pathway and tightly controlled cell cycle pro- gression the infected cells rely on these two mechanisms for its survival and possibly progeny formation. ... primarily determined by the color of media and cell viability by trypan blue exclusion. Cells were counted for the number of living cells every 24–48 hrs. Subsequent...

Ngày tải lên: 10/08/2014, 05:21

... also go to the elders and farmers of the study area for their support and co-operation during the study. The help of Mr. Obrien Nyarko and other staff of MOFA, Ejura, during the fieldwork and Mr. ... 6:11 http://www.ethnobiomed.com/content/6/1/11 Page 12 of 15 Major feeds in Group 2 were maize grains, cassava peels and yam peels, in the category of crops and...

Ngày tải lên: 10/08/2014, 09:21

... Reform Right: A Guide To Improving Performance And Equity Oxford: Oxford University Press 2003. 28. Institute of Medicine: Crossing The Quality Chasm: A New Health System For The 21st Century ... paucity of inter- actions with the healthcare system, paucity of critical health outcomes, and availability of quality of life and prevention metrics. These factors have vario...

Ngày tải lên: 11/08/2014, 05:21

... contributions KKB, SAH and EBH performed all of the in vivo studies and analyzed the data. LH performed all the in vitro stud- ies and analyzed the data. MB designed and prepared the formulations for the p38 ... models. Therefore, the inhibition of proinflammatory cytokines may provide an important therapeutic approach for the treatment of OA. Clinical trial...

Ngày tải lên: 11/08/2014, 08:22