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Báo cáo y học: " The role of the bronchial microvasculature in the airway remodelling in asthma and COPD" pps

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Báo cáo y học: " Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation" ppt

... provided the knockout mice used in the study. PS and NW generated the recombinant TF.Figure 5 Role of fibrin in soluble tissue factor-induced inflammationRole of fibrin in soluble tissue factor-induced ... afterinjection.Fibrin formation and deposition was significantly diminished in PAR-4-deficient mice and underlines the important role of fibrin in inflammation. These may be mediated by fibrin-induced ... Fibrin immunostaining in the footpad was gradedindependently by two observers unaware of animal treatmenton a scale of zero (no fibrin at all) to six (maximum of fibrinstaining). Lymphocyte and...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx

... high and constant level of c-Myc. Also, the contribution of Ras/Raf/ERK prevented the rapid degradation of c-Myc byphosphorylation of the serine 62 residue in the N-terminal of c-Myc [24]. They ... hypothesizedthat c-Myc plays a central role in TGF1 signaling for cellgrowth stimulation. Additionally, to examine the possibility of involvement of the MAPK pathway in regulation of c-Myc sta-bility, we ... under the growth inhibitory effect of TGF1 [29-32]. The aim of the present study was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposuscells. The study was...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc

... reported on the role of cytokines in RP,either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to playmajor roles in the inflammatory process, ... scores. However, the symp-toms in these strains did not proceed in relapses as theydid in the QD and B10.Q mice, and therefore resulted in alower mean score than for the other strains (Fig. 1c).Table ... anti-inflammatorymediators as well as proinflammatory ones. The cytokineinterleukin-10 (IL-10) has been in focus for many years in autoimmune arthritis and in other autoimmune diseases.The...
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Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... of YgfZ followed byFigure 2 Different roles played by YgfZ and SodA in counteracting plumbagin. The ΔygfZ and ΔsodA strains were transformed with pQE-sodA and pQE-ygfZ to express SodA and YgfZ, ... and the Δyg fZstrains and the parental strain were tested (Table 3).Therefore, adding a methyl group to the 3-position of naphtho quinone ring apparently diminishes the plumba-gin toxicity ... activities of different YgfZ constructs to support the growth of the ΔygfZ E. coli strain in the presence of plumbagin. Plasmids were separately transformed into the ΔygfZ strain and assayed for the diameters...
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Báo cáo y học: "Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries" ppsx

... by sub-acu te and chronic low back pain and/ or sciatica: this exerts animportant impact on the quali ty of life, causing interfer-ence of sleep and enjoyment of life.Many clinical studies ... of Physical Medicine and Rehabilitation, University of Foggia,Foggia, ItalyFull list of author information is available at the end of the articleRanieri et al. Journal of Brachial Plexus and ... 2009 of the Journal of Brachial Plexus and Peripheral Nerve Injury [1]. Wecongratulate the Jour nal for the interest in this topic.This innovative study demonstrated the protective effect of a-lipoic...
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Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot

Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot

... for the hypothesis that Cys341 is not only located at the S1binding site [5–7,9], but the hydrophobicity of the thiolgroup also plays a role in substrate binding and interacting with the hydrophobic ... thiol group (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1 subsite induced by the interaction ... DG‡ðmutantÞÀDG‡ðwild-typeÞwhere DGsis the binding energy of the substrate to the enzyme, DGàis the activation energy in the chemical steps of bond making and breaking, DG‡Tis the activation energy forthe...
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Báo cáo Y học: Genomic organization of MUC4 mucin gene Towards the characterization of splice variants potx

Báo cáo Y học: Genomic organization of MUC4 mucin gene Towards the characterization of splice variants potx

... serineresidues carrying O-linked glycan chains and distributed in tandemly repeated motifs in the central part of the proteinbackbone. Mucins are known to play important roles in the lubrication and protection ... single cell type may result in modulation of the properties of the molecule. On the otherhand, the alternative RNA splice forms may only functionto reduce the level of expression of the main ... with the b-catenin [31].This interaction is regulated mainly by two mechanisms, via the phosphorylation status of each partner of the b-cateninpathwaycausedbytheGSK3b, or via the interaction of MUC1...
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Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx

... article by Terry Smith and William Cruikshank in the Journal of Immunology provides fascinating yetunexpected insights into how autoantibodies contribute to the maintenance of inflammatory disease ... chronic inflammation (both local and systemic), and alterations in the immune response, including changes in the T-cell repertoire and the production of autoantibodies[1]. The precise nature of these ... activity and T-cell trafficking. In addition,they are of potential importance for the development of innovative therapeutic strategies, in which interrupting the IGF-1/IGF-1R axis could result in...
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Báo cáo y học: " Prompt improvement of a pressure ulcer by the administration of high viscosity semi-solid nutrition via a nasogastric tube in a man with tuberculosis: a case report" pdf

... kcal/day.On day 21 in hospital, a semi-solid enteral product of 400 kcal/267 g ( PG Soft™,Terumo,Tokyo,Japan)wasadministered for 15 minutes 3 times a day, which wasthen followed by 250 mL of semi-solidified ... ornose wings accompanying insertion of the nasogastrictube was observed. Compliance of the large-bore naso-gastri c tube was favorable, and he did not try to remove the tube himself. With continuous ... apatientwhohasproblemsswallowingbuthasanintactintestinal tract, enteral nut rition is primarily recom-mended [1]. Semi-solid enteral nutrition has the advan-tage of lowering the risk of diarrhea and esophagealreflux...
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