Báo cáo y học: "Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis" pps

... necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis Laure Delavallée 1 , Luca Semerano 1,2 , Eric Assier 1 , ... area by inflammatory cells; 3 = severe inflammation and massive invasion of adjacent tis- sues by pannus [17]. Other sections were scored for loss of safr...

Ngày tải lên: 12/08/2014, 11:22

... 1343–1354. 7. Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A. , Akiba,H.,Okuma,K.&Yagita,H.(1999)Involvementof TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. ... observations, structural changes of TRAIL induced by acidification reveal that TRAIL might have a potential acid-enhanced cytotoxicity and its intrinsic property be also shared by...

Ngày tải lên: 31/03/2014, 08:20

... particular, appear to rapidly reduce inflammation, and probably also reduce vascular permeability, in patients with inflammatory manifestations of SLE. Autoantibodies under tumor necrosis factor blockade ... necrosis factor-alpha and lymphotoxin alpha/beta in immunity and autoimmunity. Arthritis Res 2002, 4:S141-S152. 3. Mageed RA, Isenberg DA: Tumour necrosis factor alpha...

Ngày tải lên: 09/08/2014, 10:22

... pro -inflammatory cytokine primarily produced by activated macrophages, is thought to play a critical role in the pathogenesis of COPD by promoting and maintaining the expression and release of various ... presence of small airway and lung parenchyma inflammation in smokers and COPD patients [3,4,16,26-28]. Local inflammation is characterized by increased numbers of infl...

Ngày tải lên: 11/08/2014, 03:20

... individuals, statistical analysis and interpret the data and draft the final manuscript; NRGP: performed the medical assessment; AYOA: conducted the laboratory analysis; CRC: laboratory analysis; ... by promoting and maintaining the expression and release of various proin- flammatory mediators which lead to tissue damage and remodeling [13,14]. Very little is known about the mechanism...

Ngày tải lên: 11/08/2014, 06:22

... there is no commerc ially available s oftware to deal with data of this sort in longitudinal analysis. As a result we have perf ormed two separate analyses exam- ining, 1) BML size change at all ... method of mea- surement ranged from 2.2 to 2.6% [34]. Statistical analysis In order to examine the natural history of BMLs a sig- nificant change in BML size was defined as...

Ngày tải lên: 12/08/2014, 15:22

... therapeutic use of warfarin and ibuprofen may affect haem transfer to hemopexin and consequently its plasma level. In parallel, haem may affect pharmacokinetics of drugs carried out by HSA. ACKNOWLEDGEMENTS The ... that the flexibility of the HSA structure allows it to adapt readily to ligands and that its three-domain design provides a variety of binding sites. In particul...

Ngày tải lên: 31/03/2014, 23:20

... analysis of data. CA performed the statistical analysis and the clinical associa- tions. AS participated in the analysis and interpretation of data and in the revision of the manuscript. RR participated ... endothelial cell line and apoptosis and participated in the design of the study and helped to draft the manuscript. FC participated in the design of the study and...

Ngày tải lên: 09/08/2014, 06:23

... Bettadapura J, Slavin AJ, Old L, Bernard CC: TNF is a potent anti -inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998, 4:78-83. 6. Kassiotis G, Kollias G: Uncoupling the proinflammatory ... Cope AP: Exploring the reciprocal relationship between immunity and inflammation in chronic inflammatory arthritis. Rheumatology (Oxford) 2003, 42:716-731. 11. Ma X, Sun...

Ngày tải lên: 09/08/2014, 10:23

... Multivariate analysis Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis Demographic Age at start of therapy (years) 0.99 (0.98 to 1.00) 0.99 (0.98 to 1.00) 0.99 ... analysis for drug discontinuation due to inefficacy and adverse events Variable Overall withdrawal Withdrawal due to inefficacy Withdrawal due to adverse events Univariate analys...

Ngày tải lên: 09/08/2014, 14:20