Báo cáo y học: " New insights in understanding the pathogenesis of spondyloarthropathies" pdf

... that the understanding of the different pathways to inflammation will facilitate the assessment of disease activity and will improve targeting of therapies [5]. Abbreviations AS = ankylosing ... as: van der Horst-Bruinsma IE, Crusius JBA: New insights in understanding the pathogenesis of spondyloarthropathies. Arthritis Research & Therapy 2010, 12:102. Page 2...

Ngày tải lên: 12/08/2014, 11:22

... in which male mice are treated with the alkylating agent ethinyl- nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring ... require computation of risk from combinations of markers. The current capacity of these tests to predict fracture is illustrated in Figure 1. Using the findings from th...

Ngày tải lên: 09/08/2014, 10:23

... least one innervated rectus was required to re-establish the integrity of the abdominal wall [7]. The idea of mesh augmentation in the midline was aban- doned owing to the fact that, in the present ... assisted in providing a critical appraisal of the manu- script. VS performed the surgery, was involved in all inves- tigations and assisted in the literature s...

Ngày tải lên: 11/08/2014, 23:21

... intelligibility rat- ing. Externally, the rating for intelligibility was the same for the monolinguals and the bilinguals, in the sense that they were both rating precisely the same materials on the ... explained on the basis of the instructions to the Russian readers, which were to use any ingenuity or knowledge of Russian they might have to divine the mean...

Ngày tải lên: 19/02/2014, 19:20

... implanted beneath the skin on the lateral side of the neck by surgi- cally making an incision and developing a pocket about 2 cm beyond the incision site. The pellet was placed in the pocket and the incision ... mixed thoroughly. Up to 700 μl of the sample including any pre- cipitate that may have formed was transferred into an RNeasy Mini Spin Column. The column was t...

Ngày tải lên: 12/08/2014, 14:22

... a tyrosine phosphatase that inter- acts with FAK and negatively regulates integrin-mediated cell spreading, is not expressed in RA-SFs of the most superficial lining layer and at sites of invasion ... regulation of integrin sig- nalling in RA-SFs and the relevance of Src-PTK/FAK for- mation for synovial cell activation. This is in striking contrast to the multitude of da...

Ngày tải lên: 09/08/2014, 01:22

... through the descending inhibitory pain pathways in the brain and spinal cord [8-10]. Dysfunction in serotonin and nor- epinephrine in these pain inhibitory pathways may contribute to the central ... that increase the activity of serotonin and norepinephrine may correct a functional deficit of serotonin and norepinephrine neuro- transmission in these descending inhibitory p...

Ngày tải lên: 09/08/2014, 08:22

... these are present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects ... Therapy, Barthel and collaborators give new infor- mation on the existence of neurotrophin production in the synovial tissue of arthritic joints. These findings,...

Ngày tải lên: 09/08/2014, 14:22

... pathway and cytolysis of type 1 and type 2 alveolar epithelial cells and helps in the dissemination of M. tuberculosis [20,70]. The released bacilli multiply extracellularly, are phago- cytosed by ... This is further com- pounded by the differences that exist in the manner in which these tests are applied for the detection of latently infected individuals in different...

Ngày tải lên: 12/08/2014, 13:22

... moment, the fundamental resources and systems needed for the care of the critically ill patient are (a) staff, (b) the ways that they interact with each other, and (c) the non-human elements of systems ... stories are all skills of individual clinicians. The team-related issues that the study uncovered reflect the teamwork component of the system. Finally, the stru...

Ngày tải lên: 13/08/2014, 16:20