Báo cáo y học: "Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment" pot

... article Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval ... increased therapeutic potency of liposomal DXM- P resulted also in a significant reduction of urinary pyridinoline, indicating an...

Ngày tải lên: 12/08/2014, 11:22

... pathogenesis of rheuma- toid arthritis. J Rheumatol 1998, 53(suppl):S3-S7. 2. Panayi GS, Lanchbury S, Kingsley GH: The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid ... administration was repeated four times with an interval of 3–4 days. Delayed-type hypersensitivity assay Peptides were dissolved in PBS (2 mg/ml) and 50 µl was inject...

Ngày tải lên: 09/08/2014, 03:24

... formal examination of sw ollen joints (swollen joint count using 28 joints, or SJC28) and tender joints (tender joint count using 28 joi nts, or TJC28), global est imate of dis- ease activity, and erythrocyte ... severity. In an ideal world, a reduction of work disability rates in RA patients might be achieved by initiating early and aggressive treatm ent within some weeksormont...

Ngày tải lên: 12/08/2014, 12:20

... recent proof -of- principle study high- lighted the utility of these double-transgenic rats for a rapid preclinical evaluation of the inhibitory potency and of the pharmacokinetic properties of antiviral ... gene expression from the HIV-1 long terminal repeat (LTR) occurred in cell lines from mice and hamsters only in the presence of Cyclin T1 of human origin [15]. Ortholo...

Ngày tải lên: 13/08/2014, 05:22

... obtained from review of a very large number of bony regions (1013) by two readers working completely independ- ently in different institutions. A high degree of inter-reader reli- ability was demonstrated ... group than in those with non-AM ero- sive PsA, despite there being no evidence of greater disease activity in terms of clinical scores (skin or joint) or inflammatory m...

Ngày tải lên: 09/08/2014, 01:22

... Combination Therapy Trial Group: Delay to institution of therapy and induc- tion of remission using single-drug or combination-disease- modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis ... DG, Symmons DP, Silman AJ: Influence of disease-modifying therapy on radi- ographic outcome in inflammatory polyarthritis at five years: results from a large ob...

Ngày tải lên: 09/08/2014, 01:23

... lines of evidence implicate NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener- Figure 3 NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine ... shown in our study, individuals vary substantially in their dietary intake of nitrate and nitrite. Unless individual variability of NOx intake is taken into account, me...

Ngày tải lên: 09/08/2014, 08:22

... Sugawara K, Ikenaka T: Conver- sion of peanut trypsin-chymotrypsin inhibitor B-III to a chymo- trypsin inhibitor by deimination of the P1 arginine residues in two reactive sites. J Biochem 1987, ... joint [14,37]. Neverthe- less, citrullinated fibrinogen is generated in inflamed synovia arising from a variety of inflammatory conditions [37]. Our observation that ICs containing cit...

Ngày tải lên: 09/08/2014, 10:23

... efficient treatment of RA in Spain. Throughout the follow-up of the EMECAR cohort, the percentage of patients without any DMARD declined while the frequency of patients on combined therapy increased. In addition, ... funded by the Spanish Society of Rheumatology, the Spanish Foundation of Rheumatology, and by an independent research grant from Aventis, formerly from Hoechs...

Ngày tải lên: 09/08/2014, 13:22

... addition of the PIP and DIP joints. These data were obtained from review of a very large number of bony regions (1013) by two readers working completely independ- ently in different institutions. ... clinical assess- ments including collection of demographic data, as well as dis- ease activity scores (DAS) obtained from history, examination and laboratory investigations includin...

Ngày tải lên: 09/08/2014, 13:22