Báo cáo y học: "RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies" potx

... of local and systemic inflammation, and partially reduced local but not systemic bone loss in AIA and CIA rats. RANKL inhibition prevented local and systemic bone loss without significantly inhibiting ... arthritic joints. Effects of anti-TNFα, anti-IL-1, or anti-RANKL therapy on local and systemic bone loss Local bone loss within inflamed hind paw...

Ngày tải lên: 12/08/2014, 11:22

... Norway 2 Faculty of Medicine, University of Oslo, Oslo, Norway 3 Institute of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway Corresponding author: ... from Luminex Corporation, Austin, USA). The multiplex assay sys- tem has been validated against the traditional ELISA sandwich assay for cytokines and found to perform very reliably [5]. Measured cy...

Ngày tải lên: 09/08/2014, 10:23

... are capable in some cases of mediating regression of tumors [53,54]. In ammatory in ltrates comprised of eosinophils may also play an important role at the primary site of tumor regression by releasing ... that ECP may interact prefe ren- tially with a receptor or binding protein on t he cell surface. We attempted to observe the speci®c binding using ECP and RITC-labeled ECP by mo...

Ngày tải lên: 17/03/2014, 17:20

... and no inhibition by p38 MAPK inhibitor was observed. This latter finding is in accordance with the study by Lai and co-workers showing that LPS induction of MMP9 in monocytes is mainly regu- lated ... the synovium [10]. The lining layer consists mainly of fibroblasts and macrophages, both important players in the process of inflammation by the production of cytokines and de...

Ngày tải lên: 09/08/2014, 01:23

... antibody (sc847; Santa Cruz Biotechnology). Blots were blocked in blocking buffer (5% non-fat drymilk in PBS) for two hours, incubated for one hour with primary antibody diluted in blocking buffer 1:200 ... E- selectin [29] and VCAM-1 [30]. We previously reported that anti-E-selectin antibody-directed PEGylated adenovirus selec- tively homed to inflamed skin in mice with a delay...

Ngày tải lên: 09/08/2014, 07:20

... for signs of arthritis in each paw according to the following scale: 0 = no swelling or redness/ normal paw; 1 = swelling and /or redness in one digit; 2 = swelling and /or redness in two or more ... of inflammatory swelling, cell influx and cartilage damage Figure 2 Clinical scores from murine collagen-induced arthritis study 2Clinical scores from murine collagen-induced a...

Ngày tải lên: 09/08/2014, 10:22

... activation by plant extracts or constituents has been reported repeatedly [24]. Blocking IκB kinase activity has been reported as the underlying mechanism for restricting NF-κB activation by green ... that bioavailable active principles of Pycnogenol exert anti-inflammatory effects by inhibition of proinflammatory gene expression which is consistent with documented clinical observ...

Ngày tải lên: 11/08/2014, 08:21

... was studied using a gel-shift assay. In this assay, the EGSs were incubated with the substrate to allow for bind- ing, and the EGS-UL49 mRNA complexes were separated in polyacrylamide gels under ... days postinfection. The viral stocks were prepared by adding an equal volume of 10% skim milk, followed by sonication. The titers of the viral stocks were determined by infecting 2 × 1...

Ngày tải lên: 12/08/2014, 04:20

... may lack target sequences for trans -inhibition by AS19. Mechanism of trans -inhibition by HIV-lhNef and the AS variants We have previously described strong inhibition of HIV-1 by RNAi-inducing ... b.berkhout@amc.uva.nl * Corresponding author Abstract Background: Human immunodeficiency virus type 1 (HIV-1) can be inhibited by means of RNA silencing or interference (RNAi) using...

Ngày tải lên: 13/08/2014, 09:20

... for citation purposes) Retrovirology Open Access Correction Correction: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120 James M Binley 1 , ... Biology, The Scripps Research Institute, 10666 North Torrey Pines Rd. La Jolla, CA 92037, USA Email: James M Binley - jbinley@tpims.org; Stacie Ngo-Abdalla - stacie_ngo@yahoo.com; Pen...

Ngày tải lên: 13/08/2014, 09:20