Báo cáo y học: " Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle" doc

... Recently, it has been shown that acetylcholine, by acting on muscarinic receptors, is also involved in airway inflammation and remodelling. The mechanism(s) by which muscarinic receptors regulate inflammatory ... synergistic effect of muscarinic receptor stimulation with CSE PKC plays an important role as a signalling intermedi- ate in pro-inflammatory cytokine secretion b...

Ngày tải lên: 12/08/2014, 11:22

... sensitivity of HIV-1 macrophages through the inhibition of the activity of the pro-survival cytokine macrophage colony-stimu- lating factor (M-CSF) [162]. Finally, several AKT inhibi- tors including ... could syner- gistically reactivate HIV-1 replication in latently promonocytic cells by increasing the ratio of Sp1/Sp3 [100]. Serpin B2, a serine protease inhibitor induced in acti...

Ngày tải lên: 12/08/2014, 23:23

... respectively, instead of the calyx cells. Further, the expression of IEP proteins is not synchronized with that of CkPDV capsid proteins; IEP proteins were observed approximately one day after the initiation ... (IEP-1) deter- mined in the prior study [21] is underlined. The amino acid sequence (10 amino acids) of IEP-2 determined in the present study is also underlined. Potential...

Ngày tải lên: 31/03/2014, 15:20

... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta- catenin through inactivation of the intrinsic catalytic activity of the receptor- type protein ... Perez-Pinera P, Deuel TF: Fyn is a downstream target of the pleiotrophin /receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation o...

Ngày tải lên: 12/08/2014, 11:22

... reasonable sensitivity of 89.7% but a low specificity of 38.6%. That study served to highlight the inadequacy of clinical scoring systems in the assessment of sedation in those receiving neuromuscular blocking ... monitoring sedation in critically ill children, but that this role has yet to be clearly defined. It must be remembered that the optimal range of BIS scores for vary...

Ngày tải lên: 12/08/2014, 20:20

... only by dyspnoae, but also by RV dysfunction leading to BNP release. In hemodynamically stable patients, RV dysfunc- tion as observed by echocardiography has been shown to be able to identify ... PE. Table 1 Characteristics of included studies Reference Study design Patients, number Hemodynamic instability (number) Timing of BNP sampling Thrombolysis, number Age, years Male, percen...

Ngày tải lên: 13/08/2014, 11:22

... air- ways is increased activity of arginase, which hydrolyzes L- arginine into L-ornithine and urea [10]. Arginase is expressed in the airways [12] and has shown to be func- tionally involved in ... Remarkably, inhibition of arginase activity by the specific inhibitor N ω -hydroxy-nor-L- arginine (nor-NOHA) completely reversed the airway hyperreactivity to the level of unchallenge...

Ngày tải lên: 12/08/2014, 16:20

... Hawrylowicz CM, O’Garra A: In vitro generation of interleukin 10-producing regulatory CD4 + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. ... activation of naive T cells in vivo. When ligands become receptors: the induction of indoleamine 2,3-dioxygenase (IDO) by T reg cells expressing CTLA-4 The linkage between reg...

Ngày tải lên: 09/08/2014, 01:24

... revealed other MyD88-independent signalling pathways involving the Toll-IL-1 receptor (TIR) domain-containing adaptor molecules TRIF (TIR domain-containing adaptor protein-inducing- interferon beta) ... immunity PAMPs that ligate TLRs induce potent mechanisms of innate antimicrobial immunity. TLRs that signal through MyD88 induce NF-κB-dependent expression of pro-inflammatory cytoki...

Ngày tải lên: 09/08/2014, 07:20

... possible. The family structure of each of the 163 offspring ranged through one off- spring per family (n = 48), two offspring per family (35 families, n = 70), three offspring per family (9 families, ... measures of physical activity included measurement of muscle strength by dynamometry at the lower limb (involving both legs simultaneously). The subject was instructed in each techn...

Ngày tải lên: 09/08/2014, 07:20